CCDC88A

CCDC88A
Identifiers
Aliases	CCDC88A, APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, coiled-coil domain containing 88A, PEHO, PEHOL
External IDs	OMIM: 609736; MGI: 1925177; GeneCards: CCDC88A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	55,419,895 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	29,460,808 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; corpus callosum; ; ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; subthalamic nucleus; ; buccal mucosa cell; ; inferior ganglion of vagus nerve; ; tendon of biceps brachii; ; testicle;
	Top expressed in
	Rostral migratory stream; ; barrel cortex; ; tail of embryo; ; genital tubercle; ; lateral septal nucleus; ; lateral geniculate nucleus; ; mammillary body; ; ventromedial nucleus; ; spermatid; ; anterior amygdaloid area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; phosphatidylinositol binding; actin binding; microtubule binding; protein kinase B binding; dynein light intermediate chain binding; G-protein gamma-subunit binding;
Cellular component	cytoplasm; Golgi apparatus; cell projection; endoplasmic reticulum; lamellipodium; membrane; cytoplasmic vesicle; cytosol; plasma membrane; cell leading edge; centrosome; centriole; cytoskeleton; ciliary basal body; COPI-coated Golgi to ER transport vesicle;
Biological process	regulation of actin cytoskeleton organization; nervous system development; DNA replication; membrane organization; cell migration; lamellipodium assembly; activation of protein kinase B activity; regulation of DNA replication; TOR signaling; regulation of protein phosphorylation; regulation of cell population proliferation; regulation of neuron projection development; cell projection organization; cytoskeleton-dependent intracellular transport; cytoplasmic microtubule organization; positive regulation of cilium assembly; positive regulation of protein localization to cilium;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55704
	108686
	ENSG00000115355
	ENSMUSG00000032740
	Q3V6T2
	Q5SNZ0
	NM_001135597; NM_001254943; NM_018084; NM_001365480
	NM_176841; NM_001363368; NM_001363369
	NP_001129069; NP_001241872; NP_060554; NP_001352409
	NP_789811; NP_001350297; NP_001350298
	Wikidata
View/Edit Human	View/Edit Mouse

Girdin is a protein that in humans is encoded by the CCDC88A gene. Although its cellular function are not fully elucidated, it has been associated with glioma.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115355 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032740 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (June 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". The Journal of Biological Chemistry. 280 (23): 22012–22020. doi:10.1074/jbc.M501833200. PMID 15749703.
↑ Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, et al. (May 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". The Journal of Biological Chemistry. 280 (18): 18525–18535. doi:10.1074/jbc.M500586200. PMID 15753085.
↑ "Entrez Gene: KIAA1212 KIAA1212".
↑ Gu F, Wang L, He J, Liu X, Zhang H, Li W, et al. (November 2014). "Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells". Journal of Neurochemistry. 131 (4): 457–469. doi:10.1111/jnc.12831. PMID 25060559. S2CID 206090300.

External links

DISC1 Players Gird For Adult Neurodevelopment - Schizophrenia Research Forum, 8 oct 2009
Human CCDC88A genome location and CCDC88A gene details page in the UCSC Genome Browser.

Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, et al. (March 2008). "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin". Nature Cell Biology. 10 (3): 329–337. doi:10.1038/ncb1695. PMID 18264090. S2CID 23157573.
Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, et al. (September 2005). "Akt/PKB regulates actin organization and cell motility via Girdin/APE". Developmental Cell. 9 (3): 389–402. doi:10.1016/j.devcel.2005.08.001. PMID 16139227.
Simpson F, Martin S, Evans TM, Kerr M, James DE, Parton RG, et al. (June 2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6). Copenhagen, Denmark: 442–458. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–1101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–345. doi:10.1093/dnares/6.5.337. PMID 10574462.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115355 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032740 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Le-Niculescu_2005-5] Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (June 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". The Journal of Biological Chemistry. 280 (23): 22012–22020. doi:10.1074/jbc.M501833200. PMID 15749703.

[Anai_2005-6] Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, et al. (May 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". The Journal of Biological Chemistry. 280 (18): 18525–18535. doi:10.1074/jbc.M500586200. PMID 15753085.

[entrez-7] "Entrez Gene: KIAA1212 KIAA1212".

[8] Gu F, Wang L, He J, Liu X, Zhang H, Li W, et al. (November 2014). "Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells". Journal of Neurochemistry. 131 (4): 457–469. doi:10.1111/jnc.12831. PMID 25060559. S2CID 206090300.

CCDC88A

References

External links

Further reading