CCDC90B

CCDC90B
Identifiers
Aliases	CCDC90B, MDS011, MDS025, coiled-coil domain containing 90B
External IDs	MGI: 1913615; GeneCards: CCDC90B
Gene location (Human)
Chr.	Chromosome 11 (human)
End	83,286,390 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	92,231,502 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Achilles tendon; ; sperm; ; C1 segment; ; left testis; ; right testis; ; corpus callosum; ; right adrenal cortex; ; gonad;
	Top expressed in
	atrioventricular valve; ; medial ganglionic eminence; ; vestibular membrane of cochlear duct; ; intercostal muscle; ; zygote; ; transitional epithelium of urinary bladder; ; vestibular sensory epithelium; ; epithelium of lens; ; endocardial cushion; ; secondary oocyte;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	60492
	66365
	ENSG00000137500
	ENSMUSG00000030613
	Q9GZT6
	Q8C3X2
NM_001286116; NM_001286117; NM_001286118; NM_001286119; NM_001286120;
	NM_021825
	NM_001162918; NM_025515
NP_001273045; NP_001273046; NP_001273047; NP_001273048; NP_001273049;
	NP_068597
	NP_001156390; NP_079791
	Wikidata
View/Edit Human	View/Edit Mouse

Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene. It is a mitochondrial calcium uniporter binding protein.

Gene

CCDC90B is located on chromosome 11 in humans. It is neighbored by:

PCF11, a mammalian pre-mRNA cleavage complex 2 protein
ANKRD42, ankyrin repeat protein involved with calcium ion bonding
BC070093
DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family

Structure

This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.

The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.

Properties

Molecular Weight: 26.72 kDa
Isoelectric point: 7.5
Transmembrane Helices: None

Post-translation modifications:

Chloroplast transit peptides: None

Signal pepties: None

C-mannosylation sites: None

N-glycosylation sites: None

Mitochondrial targeting: Yes

Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP

It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137500 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030613 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Adlakha J, Karamichali I, Sangwallek J, Deiss S, Bär K, Coles M, et al. (March 2019). "Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles". Structure. 27 (3): 464–475.e6. doi:10.1016/j.str.2018.11.004. PMID 30612859.
↑ "UCSC Genome Bioinformatics BLAT". University of California - Santa Cruz. March 2006. Retrieved 2009-05-14.
↑ "ExPASy". SIB Switzerland. 2009-01-05. Retrieved 2009-05-14.

External links

Human CCDC90B genome location and CCDC90B gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137500 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030613 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Adlakha_2019-5] Adlakha J, Karamichali I, Sangwallek J, Deiss S, Bär K, Coles M, et al. (March 2019). "Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles". Structure. 27 (3): 464–475.e6. doi:10.1016/j.str.2018.11.004. PMID 30612859.

[UCSC_Genome_Bioinformatics-6] "UCSC Genome Bioinformatics BLAT". University of California - Santa Cruz. March 2006. Retrieved 2009-05-14.

[SIB_Switzerland_2009-01-05-7] "ExPASy". SIB Switzerland. 2009-01-05. Retrieved 2009-05-14.