Cyclin-dependent kinase 11A

CDK11A
Identifiers
Aliases	CDK11A, CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, PITSLRE, p58GTA, cyclin-dependent kinase 11A, cyclin dependent kinase 11A
External IDs	OMIM: 116951; MGI: 88353; GeneCards: CDK11A
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,724,357 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,649,938 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; mucosa of transverse colon; ; granulocyte; ; spleen; ; right hemisphere of cerebellum; ; pituitary gland; ; fundus; ; right lung; ; right lobe of thyroid gland; ; right testis;
	Top expressed in
	granulocyte; ; tail of embryo; ; neural layer of retina; ; saccule; ; genital tubercle; ; otic placode; ; ventricular zone; ; otic vesicle; ; epiblast; ; body of femur;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; protein serine/threonine kinase activity; protein kinase activity; ATP binding; nucleotide binding; transferase activity; protein binding; cyclin-dependent protein serine/threonine kinase activity;
Cellular component	nucleus; cytoplasm;
Biological process	regulation of transcription, DNA-templated; phosphorylation; cell cycle; regulation of cell growth; protein phosphorylation; regulation of mRNA processing; apoptotic process; regulation of mitotic cell cycle; mitotic cell cycle; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	728642
	12537
	ENSG00000008128
	ENSMUSG00000029062
	Q9UQ88
	P24788
NM_001313896; NM_001313982; NM_024011; NM_033527; NM_033529;
	NM_033532; NM_033534
	NM_007661; NM_001347308; NM_001355567; NM_001355568; NM_001355569
	NP_001300825; NP_001300911; NP_076916; NP_277071
	NP_001334237; NP_031687; NP_001342496; NP_001342497; NP_001342498
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 11A is an enzyme that in humans is encoded by the CDK11A gene (previously CDC2L2).

This gene shares very high sequence identity with a neighboring gene, CDK11B. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000008128 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029062 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lahti JM, Valentine M, Xiang J, Jones B, Amann J, Grenet J, Richmond G, Look AT, Kidd VJ (July 1994). "Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma". Nature Genetics. 7 (3): 370–5. doi:10.1038/ng0794-370. PMID 7920654. S2CID 2065302.
↑ Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, Kidd VJ (September 1998). "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2". Genome Research. 8 (9): 929–39. doi:10.1101/gr.8.9.929. PMC 310781. PMID 9750192.
1 2 "Entrez Gene: LOC728642 similar to cell division cycle 2-like 1 (PITSLRE proteins) isoform 1".

External links

Human CDK11A genome location and CDK11A gene details page in the UCSC Genome Browser.

Eipers PG, Lahti JM, Kidd VJ (July 1992). "Structure and expression of the human p58clk-1 protein kinase chromosomal gene". Genomics. 13 (3): 613–21. doi:10.1016/0888-7543(92)90132-C. PMID 1639388.
Eipers PG, Barnoski BL, Han J, Carroll AJ, Kidd VJ (November 1991). "Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15". Genomics. 11 (3): 621–9. doi:10.1016/0888-7543(91)90069-Q. PMID 1774066.
Bunnell BA, Heath LS, Adams DE, Lahti JM, Kidd VJ (October 1990). "Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle". Proceedings of the National Academy of Sciences of the United States of America. 87 (19): 7467–71. Bibcode:1990PNAS...87.7467B. doi:10.1073/pnas.87.19.7467. PMC 54768. PMID 2217177.
White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM (June 1995). "A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3". Proceedings of the National Academy of Sciences of the United States of America. 92 (12): 5520–4. Bibcode:1995PNAS...92.5520W. doi:10.1073/pnas.92.12.5520. PMC 41727. PMID 7777541.
Xiang J, Lahti JM, Grenet J, Easton J, Kidd VJ (June 1994). "Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms". The Journal of Biological Chemistry. 269 (22): 15786–15794. doi:10.1016/S0021-9258(17)40749-6. PMID 8195233.
Beyaert R, Kidd VJ, Cornelis S, Van de Craen M, Denecker G, Lahti JM, Gururajan R, Vandenabeele P, Fiers W (May 1997). "Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor". The Journal of Biological Chemistry. 272 (18): 11694–7. doi:10.1074/jbc.272.18.11694. PMID 9115219.
Loyer P, Trembley JH, Lahti JM, Kidd VJ (June 1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". Journal of Cell Science. 111 (Pt 11): 1495–506. doi:10.1242/jcs.111.11.1495. PMID 9580558.
Tang D, Gururajan R, Kidd VJ (June 1998). "Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death". The Journal of Biological Chemistry. 273 (26): 16601–7. doi:10.1074/jbc.273.26.16601. PMID 9632733.
Gururajan R, Grenet J, Lahti JM, Kidd VJ (August 1998). "Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3". Genomics. 52 (1): 101–6. doi:10.1006/geno.1998.5401. PMID 9740677.
Cornelis S, Bruynooghe Y, Denecker G, Van Huffel S, Tinton S, Beyaert R (April 2000). "Identification and characterization of a novel cell cycle-regulated internal ribosome entry site". Molecular Cell. 5 (4): 597–605. doi:10.1016/S1097-2765(00)80239-7. PMID 10882096.
Zhang SW, Xu SL, Cai MM, Yan J, Zhu XY, Hu Y, Gu JX (May 2001). "Effect of p58GTA on beta-1,4-galactosyltransferase 1 activity and cell-cycle in human hepatocarcinoma cells". Molecular and Cellular Biochemistry. 221 (1–2): 161–8. doi:10.1023/A:1010932211745. PMID 11506180. S2CID 25573580.
Berke JD, Sgambato V, Zhu PP, Lavoie B, Vincent M, Krause M, Hyman SE (October 2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron. 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997. S2CID 14486999.
Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (July 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". The Journal of Biological Chemistry. 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906.
Shi J, Feng Y, Goulet AC, Vaillancourt RR, Sachs NA, Hershey JW, Nelson MA (February 2003). "The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis". The Journal of Biological Chemistry. 278 (7): 5062–71. doi:10.1074/jbc.M206427200. PMID 12446680.
Hu D, Mayeda A, Trembley JH, Lahti JM, Kidd VJ (March 2003). "CDK11 complexes promote pre-mRNA splicing". The Journal of Biological Chemistry. 278 (10): 8623–9. doi:10.1074/jbc.M210057200. PMID 12501247.
Chen S, Yin X, Zhu X, Yan J, Ji S, Chen C, Cai M, Zhang S, Zong H, Hu Y, Yuan Z, Shen Z, Gu J (May 2003). "The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis". The Journal of Biological Chemistry. 278 (22): 20029–36. doi:10.1074/jbc.M300818200. PMID 12624090.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000008128 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029062 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7920654-5] Lahti JM, Valentine M, Xiang J, Jones B, Amann J, Grenet J, Richmond G, Look AT, Kidd VJ (July 1994). "Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma". Nature Genetics. 7 (3): 370–5. doi:10.1038/ng0794-370. PMID 7920654. S2CID 2065302.

[pmid9750192-6] Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, Kidd VJ (September 1998). "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2". Genome Research. 8 (9): 929–39. doi:10.1101/gr.8.9.929. PMC 310781. PMID 9750192.

[entrez-7] 1 2 "Entrez Gene: LOC728642 similar to cell division cycle 2-like 1 (PITSLRE proteins) isoform 1".

Cyclin-dependent kinase 11A

References

External links

Further reading