CDC42 binding protein kinase beta

CDC42BPB
Identifiers
Aliases	CDC42BPB, MRCKB, CDC42 binding protein kinase beta, CHOCNS
External IDs	OMIM: 614062; MGI: 2136459; GeneCards: CDC42BPB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QFV, 3TKU, 4UAK, 4UAL
Enzyme activity
Gene location (Human)
Chr.	Chromosome 14 (human)
End	103,057,549 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,344,152 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gastric mucosa; ; body of uterus; ; right frontal lobe; ; right hemisphere of cerebellum; ; anterior pituitary; ; left ovary; ; prefrontal cortex; ; ectocervix; ; canal of the cervix;
	Top expressed in
	zygote; ; otic vesicle; ; secondary oocyte; ; genital tubercle; ; primary visual cortex; ; superior frontal gyrus; ; yolk sac; ; tail of embryo; ; superior cervical ganglion; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; ATP binding; magnesium ion binding; protein-containing complex binding; protein binding;
Cellular component	cytoplasm; membrane; cell-cell junction; plasma membrane; cell junction; cell leading edge; actomyosin; cytoskeleton; extracellular exosome; lamellipodium; cell projection;
Biological process	intracellular signal transduction; phosphorylation; actomyosin structure organization; establishment or maintenance of cell polarity; protein phosphorylation; cytoskeleton organization; cell migration; signal transduction; actin cytoskeleton organization; actin cytoskeleton reorganization; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9578
	217866
	ENSG00000198752
	ENSMUSG00000021279
	Q9Y5S2; Q86XZ8
	Q7TT50
	NM_006035
	NM_183016
	NP_006026; NP_006026.3
	NP_898837
	Wikidata
View/Edit Human	View/Edit Mouse

CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene.

Function

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rats suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198752 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021279 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CDC42 binding protein kinase beta". Retrieved 2017-05-31.

Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM (2008). "Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta". J. Biol. Chem. 283 (16): 10543–9. doi:10.1074/jbc.M707463200. PMC 2447637. PMID 18263588.
Kim YJ, Kim NY, Lee MK, Choi HJ, Baek HJ, Nam CH (2010). "Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients". Exp. Mol. Med. 42 (5): 319–26. doi:10.3858/emm.2010.42.5.030. PMC 2877252. PMID 20177145.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M (2011). "Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration". EMBO J. 30 (4): 665–78. doi:10.1038/emboj.2010.353. PMC 3041950. PMID 21240187.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198752 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021279 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CDC42 binding protein kinase beta". Retrieved 2017-05-31.

CDC42 binding protein kinase beta

Function

References

Further reading