CDCA3

CDCA3

Identifiers

CDCA3, GRCC8, TOME-1, cell division cycle associated 3, TOME1

External IDs

OMIM: 607749; MGI: 1315198; GeneCards: CDCA3

Gene location (Human)

Chr.	Chromosome 12 (human)

Band	12p13.31	Start	6,844,793 bp
Band	12p13.31	End	6,851,292 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6 F2\|6 59.17 cM	Start	124,806,510 bp
Band	6 F2\|6 59.17 cM	End	124,810,664 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ventricular zone

oocyte

secondary oocyte

gonad

left testis

right testis

ganglionic eminence

duodenum

jejunal mucosa

mucosa of transverse colon

Top expressed in

ventricular zone

fetal liver hematopoietic progenitor cell

medial ganglionic eminence

genital tubercle

tibiofemoral joint

spermatid

tail of embryo

seminiferous tubule

spermatocyte

abdominal wall

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	cytosol cytoplasm
Biological process	cell division cell cycle protein ubiquitination biological process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


83461


14793


ENSG00000111665


ENSMUSG00000023505


Q99618


Q99M54

RefSeq (mRNA)


NM_001297602 NM_001297603 NM_001297604 NM_031299 NM_001331019


NM_013538

RefSeq (protein)


NP_001284531 NP_001284532 NP_001284533 NP_001317948 NP_112589


NP_038566

Location (UCSC)

Chr 12: 6.84 – 6.85 Mb

Chr 6: 124.81 – 124.81 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Cell division cycle-associated protein 3 is a protein that in humans is encoded by the CDCA3 gene.

Interactions

CDCA3 has been shown to interact with SKP1A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111665 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023505 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (May 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
↑ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
↑ "Entrez Gene: CDCA3 cell division cycle associated 3".
↑ Ayad, Nagi G; Rankin Susannah; Murakami Monica; Jebanathirajah Judith; Gygi Steven; Kirschner Marc W (Apr 2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1). United States: 101–13. doi:10.1016/S0092-8674(03)00232-0. ISSN 0092-8674. PMID 12679038.

External links

Human CDCA3 genome location and CDCA3 gene details page in the UCSC Genome Browser.

Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yoshida K (2005). "Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters". FEBS Lett. 579 (6): 1488–92. doi:10.1016/j.febslet.2005.01.055. PMID 15733861. S2CID 19511881.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ayad NG, Rankin S, Murakami M, et al. (2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1): 101–13. CiteSeerX 10.1.1.522.1877. doi:10.1016/S0092-8674(03)00232-0. PMID 12679038. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.

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