Centromere protein C

CENPC
Identifiers
Aliases	CENPC, CENP-C, CENPC1, MIF2, hcp-4, centromere protein C
External IDs	OMIM: 117141; MGI: 99700; GeneCards: CENPC
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,545,503 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,213,442 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; corpus callosum; ; bone marrow cell; ; testicle; ; tonsil; ; body of pancreas; ; gonad; ; ventricular zone; ; lymph node;
	Top expressed in
	spermatocyte; ; tail of embryo; ; genital tubercle; ; ventricular zone; ; Gonadal ridge; ; otic placode; ; superior cervical ganglion; ; abdominal wall; ; otic vesicle; ; saccule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; centromeric DNA binding; protein binding; identical protein binding;
Cellular component	pericentric heterochromatin; chromosome; chromosome, centromeric region; kinetochore; nucleus; nucleoplasm; cytosol; nuclear body; midbody; cleavage furrow; intercellular bridge; Flemming body;
Biological process	chromosome segregation; cell division; kinetochore assembly; cell cycle; CENP-A containing chromatin assembly; attachment of mitotic spindle microtubules to kinetochore; monopolar spindle attachment to meiosis I kinetochore; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1060
	12617
	ENSG00000145241
	ENSMUSG00000029253
	Q03188
	P49452
	NM_001812; NM_001362481
	NM_007683; NM_001345902; NM_001345903; NM_001345904
	NP_001803; NP_001349410
	NP_001332831; NP_001332832; NP_001332833; NP_031709
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein C is a protein that in humans is encoded by the CENPC gene (previously CENPC1).

Centromere protein C is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145241 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029253 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ McKay S, Thomson E, Cooke H (Dec 1994). "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes". Genomics. 22 (1): 36–40. doi:10.1006/geno.1994.1342. PMID 7959789.
1 2 "Entrez Gene: CENPC1 centromere protein C 1".

External links

Human CENPC genome location and CENPC gene details page in the UCSC Genome Browser.

Saitoh H, Tomkiel J, Cooke CA, et al. (1992). "CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate". Cell. 70 (1): 115–25. doi:10.1016/0092-8674(92)90538-N. PMID 1339310. S2CID 22014181.
Pluta AF, Earnshaw WC (1996). "Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator". J. Biol. Chem. 271 (31): 18767–74. doi:10.1074/jbc.271.31.18767. PMID 8702533.
Xie Y, Heng HH (1996). "FISH mapping of centromere protein C (CENPC) on human chromosome 4q31→q21". Cytogenet. Cell Genet. 74 (3): 192–3. doi:10.1159/000134412. PMID 8941372.
Xie Y, Ni ZM, Gu JR, et al. (1997). "Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore". Cell Res. 7 (1): 13–9. doi:10.1038/cr.1997.2. PMID 9261558.
Pluta AF, Earnshaw WC, Goldberg IG (1998). "Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death". J. Cell Sci. 111. ( Pt 14) (14): 2029–41. doi:10.1242/jcs.111.14.2029. PMID 9645950.
Song K, Gronemeyer B, Lu W, et al. (2002). "Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C)". Exp. Cell Res. 275 (1): 81–91. doi:10.1006/excr.2002.5495. PMID 11925107.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Trazzi S, Bernardoni R, Diolaiti D, et al. (2003). "In vivo functional dissection of human inner kinetochore protein CENP-C". J. Struct. Biol. 140 (1–3): 39–48. doi:10.1016/S1047-8477(02)00506-3. PMID 12490152.
Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
Suzuki N, Nakano M, Nozaki N, et al. (2004). "CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization". J. Biol. Chem. 279 (7): 5934–46. doi:10.1074/jbc.M306477200. PMID 14612452.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Chung TL, Hsiao HH, Yeh YY, et al. (2004). "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides". J. Biol. Chem. 279 (38): 39653–62. doi:10.1074/jbc.M405637200. PMID 15272016.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Faragher AJ, Sun XM, Butterworth M, et al. (2007). "Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase". Mol. Biol. Cell. 18 (4): 1337–47. doi:10.1091/mbc.E06-05-0409. PMC 1838999. PMID 17287400.
Wong LH, Brettingham-Moore KH, Chan L, et al. (2007). "Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere". Genome Res. 17 (8): 1146–60. doi:10.1101/gr.6022807. PMC 1933521. PMID 17623812.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145241 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029253 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7959789-5] McKay S, Thomson E, Cooke H (Dec 1994). "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes". Genomics. 22 (1): 36–40. doi:10.1006/geno.1994.1342. PMID 7959789.

[entrez-6] 1 2 "Entrez Gene: CENPC1 centromere protein C 1".

Centromere protein C

References

External links

Further reading