Centromere protein I

CENPI
Identifiers
Aliases	CENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I
External IDs	OMIM: 300065; MGI: 2147897; GeneCards: CENPI
Gene location (Human)
Chr.	X chromosome (human)
End	101,166,126 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,263,388 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; gonad; ; ganglionic eminence; ; testicle; ; stromal cell of endometrium; ; smooth muscle tissue; ; bone marrow; ; rectum; ; trabecular bone;
	Top expressed in
	hand; ; tail of embryo; ; dermis; ; genital tubercle; ; otic vesicle; ; abdominal wall; ; endothelial cell of lymphatic vessel; ; ventricular zone; ; renal corpuscle; ; spermatid;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	chromosome; chromosome, centromeric region; nucleoplasm; kinetochore; nucleus; cytosol; nuclear body;
Biological process	sex differentiation; centromere complex assembly; CENP-A containing chromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2491
	102920
	ENSG00000102384
	ENSMUSG00000031262
	Q92674
	Q8K1K4
	NM_006733; NM_001318521; NM_001318523; NM_001386188
	NM_145924; NM_001305631
	NP_001305450; NP_001305452; NP_006724
	NP_001292560; NP_666036
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

Function

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. CENPI is a target gene of the transcription factor E2F. Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102384 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031262 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
1 2 "Entrez Gene: CENPI centromere protein I".
1 2 Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017). "CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer". Oncotarget. 8 (37): 62167–62182. doi:10.18632/oncotarget.19131. PMC 5617495. PMID 28977935.

External links

Human CENPI genome location and CENPI gene details page in the UCSC Genome Browser.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102384 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031262 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16622420-5] Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.

[entrez-6] 1 2 "Entrez Gene: CENPI centromere protein I".

[Thangavelu2017-7] 1 2 Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017). "CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer". Oncotarget. 8 (37): 62167–62182. doi:10.18632/oncotarget.19131. PMC 5617495. PMID 28977935.

Centromere protein I

Function

References

Further reading

External links