Centromere protein O

CENPO
Identifiers
Aliases	CENPO, CENP-O, ICEN-36, MCM21R, centromere protein O
External IDs	OMIM: 611504; MGI: 1923800; GeneCards: CENPO
Gene location (Human)
Chr.	Chromosome 2 (human)
End	24,822,376 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,284,294 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; testicle; ; gonad; ; secondary oocyte; ; left testis; ; right testis; ; stromal cell of endometrium; ; mucosa of transverse colon; ; right adrenal cortex;
	Top expressed in
	primary oocyte; ; zygote; ; secondary oocyte; ; otic vesicle; ; spermatocyte; ; otic placode; ; saccule; ; lumbar subsegment of spinal cord; ; Paneth cell; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	chromosome; cytosol; chromosome, centromeric region; kinetochore; nucleoplasm; nucleus; Mis6-Sim4 complex;
Biological process	centromere complex assembly; CENP-A containing chromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	79172
	52504
	ENSG00000138092
	ENSMUSG00000020652
	Q9BU64
	Q8K015
	NM_001199803; NM_024322; NM_001322101
	NM_134046; NM_001361641
	NP_001186732; NP_001309030; NP_077298
	NP_598807; NP_001348570
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138092 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020652 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, et al. (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–457. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
↑ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–469. Bibcode:2006NaCB....8..458F. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
↑ "Entrez Gene: CENPO centromere protein O".
↑ Hewitt CA, Ling KH, Merson TD, Simpson KM, Ritchie ME, King SL, et al. (July 2010). "Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome". PLOS ONE. 5 (7) e11561. Bibcode:2010PLoSO...511561H. doi:10.1371/journal.pone.0011561. PMC 2905390. PMID 20661276.

Human CENPO genome location and CENPO gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.