ARAP2

ARAP2
Identifiers
Aliases	ARAP2, CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
External IDs	OMIM: 606645; MGI: 2684416; GeneCards: ARAP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X40, 2COD
Gene location (Human)
Chr.	Chromosome 4 (human)
End	36,244,514 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	62,923,502 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; secondary oocyte; ; corpus callosum; ; gingival epithelium; ; optic nerve; ; dorsal motor nucleus of vagus nerve; ; amniotic fluid; ; internal globus pallidus; ; middle temporal gyrus; ; Brodmann area 23;
	Top expressed in
	secondary oocyte; ; medial geniculate nucleus; ; zygote; ; hair follicle; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; primary motor cortex; ; lateral geniculate nucleus; ; inferior colliculi; ; piriform cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding;
Cellular component	cytoplasm; cytosol;
Biological process	positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	116984
	212285
	ENSG00000047365
	ENSMUSG00000037999
	Q8WZ64
	Q8BZ05
	NM_015230; NM_139182
	NM_178407
	NP_056045
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.

Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000047365 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037999 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CENTD1 centaurin, delta 1".

External links

Human ARAP2 genome location and ARAP2 gene details page in the UCSC Genome Browser.

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Yoon HY, Miura K, Cuthbert EJ, Davis KK, Ahvazi B, Casanova JE, et al. (November 2006). "ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP". Journal of Cell Science. 119 (Pt 22): 4650–4666. doi:10.1242/jcs.03237. PMID 17077126.
Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, et al. (January 2002). "ARAP1: a point of convergence for Arf and Rho signaling". Molecular Cell. 9 (1): 109–119. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, et al. (January 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Molecular Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, et al. (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–39. doi:10.1093/dnares/5.1.31. PMID 9628581.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000047365 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037999 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CENTD1 centaurin, delta 1".

ARAP2

Function

References

External links

Further reading