ARAP3

ARAP3
Identifiers
Aliases	ARAP3, CENTD3, DRAG1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
External IDs	OMIM: 606647; MGI: 2147274; GeneCards: ARAP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KG5, 2LNW, 5JD0, 5JCP
Gene location (Human)
Chr.	Chromosome 5 (human)
End	141,682,230 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	38,132,022 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lung; ; blood; ; upper lobe of left lung; ; tendon of biceps brachii; ; left ventricle; ; canal of the cervix; ; right auricle of heart; ; subcutaneous adipose tissue; ; ventricular zone;
	Top expressed in
	granulocyte; ; tail of embryo; ; yolk sac; ; genital tubercle; ; muscle of thigh; ; esophagus; ; zygote; ; embryo; ; right kidney; ; lip;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding;
Cellular component	cytosol; cell projection; membrane; plasma membrane; cytoskeleton; lamellipodium; ruffle; cytoplasm;
Biological process	positive regulation of GTPase activity; negative regulation of Rac protein signal transduction; cytoskeleton organization; regulation of small GTPase mediated signal transduction; vesicle-mediated transport; signal transduction; negative regulation of cell migration; negative regulation of Rho protein signal transduction; regulation of cell shape;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64411
	106952
	ENSG00000120318
	ENSMUSG00000024451
	Q8WWN8
	Q8R5G7
	NM_022481
	NM_001205336; NM_139206
	NP_071926
	NP_001192265; NP_631945
	Wikidata
View/Edit Human	View/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120318 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024451 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, et al. (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
↑ Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol. 12 (10): R360–2. Bibcode:2002CBio...12.R360S. doi:10.1016/S0960-9822(02)00860-6. PMID 12015138. S2CID 15875666.
1 2 "Entrez Gene: CENTD3 centaurin, delta 3".

External links

Human ARAP3 genome location and ARAP3 gene details page in the UCSC Genome Browser.

Raaijmakers JH, Deneubourg L, Rehmann H, De Koning J, Zhang Z, Krugmann S, et al. (2007). "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner". Cell. Signal. 19 (6): 1249–57. doi:10.1016/j.cellsig.2006.12.015. hdl:1874/35664. PMID 17314030. S2CID 356352.
Lu Q, Wei W, Kowalski PE, Chang AC, Cohen SN (2005). "EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin". Proc. Natl. Acad. Sci. U.S.A. 101 (49): 17246–51. doi:10.1073/pnas.0407794101. PMC 534609. PMID 15569923.
I ST, Nie Z, Stewart A, Najdovska M, Hall NE, He H, et al. (2005). "ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner". J. Cell Sci. 117 (Pt 25): 6071–84. doi:10.1242/jcs.01526. PMID 15546919.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Reinhard C, Schweikert M, Wieland FT, Nickel W (2003). "Functional reconstitution of COPI coat assembly and disassembly using chemically defined components". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8253–7. Bibcode:2003PNAS..100.8253R. doi:10.1073/pnas.1432391100. PMC 166215. PMID 12832619.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000120318 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024451 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11804589-5] Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, et al. (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.

[pmid12015138-6] Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol. 12 (10): R360–2. Bibcode:2002CBio...12.R360S. doi:10.1016/S0960-9822(02)00860-6. PMID 12015138. S2CID 15875666.

[entrez-7] 1 2 "Entrez Gene: CENTD3 centaurin, delta 3".

ARAP3

References

External links

Further reading