CHPF

CHPF

Identifiers

CHPF, CHSY2, CSS2, chondroitin polymerizing factor

External IDs

OMIM: 610405; MGI: 106576; GeneCards: CHPF

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q35	Start	219,538,954 bp
Band	2q35	End	219,543,809 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1 C4\|1 39.14 cM	Start	75,451,213 bp
Band	1 C4\|1 39.14 cM	End	75,455,951 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

decidua

anterior pituitary

stromal cell of endometrium

apex of heart

right auricle of heart

ascending aorta

left ovary

body of pancreas

right ovary

right coronary artery

Top expressed in

CA3 field

primary visual cortex

superior frontal gyrus

perirhinal cortex

entorhinal cortex

ankle joint

lactiferous gland

dentate gyrus of hippocampal formation granule cell

choroid plexus of fourth ventricle

yolk sac

More reference expression data


More reference expression data

Gene ontology
Molecular function	transferase activity acetylgalactosaminyltransferase activity protein binding metal ion binding glycosyltransferase activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
Cellular component	cytoplasm integral component of membrane Golgi cisterna membrane cytosol Golgi membrane mitochondrial matrix Golgi apparatus mitochondrion membrane
Biological process	chondroitin sulfate biosynthetic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


79586


74241


ENSG00000123989


ENSMUSG00000032997


Q8IZ52


Q6IQX7

RefSeq (mRNA)


NM_001195731 NM_024536


NM_001001565 NM_001001566

RefSeq (protein)


NP_001182660 NP_078812


NP_001001565 NP_001001566

Location (UCSC)

Chr 2: 219.54 – 219.54 Mb

Chr 1: 75.45 – 75.46 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Chondroitin sulfate synthase 2 is an enzyme that in humans is encoded by the CHPF gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123989 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032997 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ Kitagawa H, Izumikawa T, Uyama T, Sugahara K (Jun 2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J Biol Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
↑ "Entrez Gene: CHPF chondroitin polymerizing factor".

External links

Human CHPF genome location and CHPF gene details page in the UCSC Genome Browser.

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yada T, Gotoh M, Sato T, et al. (2003). "Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities". J. Biol. Chem. 278 (32): 30235–47. doi:10.1074/jbc.M303657200. PMID 12761225.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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