CHTF18

CHTF18

Identifiers

CHTF18, C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL, chromosome transmission fidelity factor 18

External IDs

OMIM: 613201; MGI: 2384887; GeneCards: CHTF18

Gene location (Human)

Chr.	Chromosome 16 (human)

Band	16p13.3	Start	788,046 bp
Band	16p13.3	End	800,737 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 A3.3	Start	25,937,900 bp
Band	17\|17 A3.3	End	25,946,393 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right testis

left testis

mucosa of transverse colon

right hemisphere of cerebellum

pancreatic ductal cell

gonad

sural nerve

ventricular zone

ganglionic eminence

granulocyte

Top expressed in

epiblast

yolk sac

internal carotid artery

external carotid artery

morula

embryo

blastocyst

embryo

ventricular zone

neural layer of retina

More reference expression data

n/a

Gene ontology
Molecular function	nucleotide binding DNA binding single-stranded DNA helicase activity protein binding ATP binding DNA clamp loader activity
Cellular component	membrane Ctf18 RFC-like complex nucleus nucleoplasm cytosol
Biological process	DNA replication cell cycle positive regulation of DNA-directed DNA polymerase activity
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


63922


214901


ENSG00000127586


ENSMUSG00000019214


Q8WVB6


Q8BIW9

RefSeq (mRNA)


NM_022092


NM_145409

RefSeq (protein)


NP_071375


NP_663384

Location (UCSC)

Chr 16: 0.79 – 0.8 Mb

Chr 17: 25.94 – 25.95 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the CHTF18 gene.

Interactions

CHTF18 has been shown to interact with:

DCC1,
PCNA,
RFC2,
RFC3,
RFC4, and
RFC5.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000127586 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019214 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
↑ "Entrez Gene: CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)".
1 2 3 4 5 Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
1 2 3 Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.

External links

Human CHTF18 genome location and CHTF18 gene details page in the UCSC Genome Browser.

Further reading

Shiomi Y, Masutani C, Hanaoka F, Kimura H, Tsurimoto T (Jul 2007). "A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity". The Journal of Biological Chemistry. 282 (29): 20906–14. doi:10.1074/jbc.M610102200. PMID 17545166.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
Naiki T, Kondo T, Nakada D, Matsumoto K, Sugimoto K (Sep 2001). "Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway". Molecular and Cellular Biology. 21 (17): 5838–45. doi:10.1128/MCB.21.17.5838-5845.2001. PMC 87303. PMID 11486023.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (Feb 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.

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