CIR1

CIRSR

Identifiers

CIRSR, CIR, corepressor interacting with RBPJ, 1, corepressor interacting with RBPJ, CIR1, CIR1, Corepressor Of RBPJ And Splicing Regulator

External IDs

OMIM: 605228; MGI: 1914185; GeneCards: CIRSR

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q31.1	Start	174,348,022 bp
Band	2q31.1	End	174,395,712 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 C3	Start	73,113,449 bp
Band	2\|2 C3	End	73,143,045 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

monocyte

Achilles tendon

olfactory zone of nasal mucosa

sural nerve

right uterine tube

right lung

gastric mucosa

skin of leg

blood

Top expressed in

bone marrow

zygote

testicle

secondary oocyte

granulocyte

primary oocyte

genital tubercle

ovary

ganglionic eminence

muscle of thigh

More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA-binding transcription factor activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription corepressor activity protein kinase binding protein-containing complex binding
Cellular component	cytoplasm histone deacetylase complex cytoskeleton nucleus microtubule organizing center nuclear speck centrosome protein-containing complex
Biological process	mRNA processing negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated RNA splicing regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9541


66935


ENSG00000138433


ENSMUSG00000041777


Q86X95


Q9DA19

RefSeq (mRNA)


NM_199075 NM_004882


NM_025854

RefSeq (protein)


NP_004873


NP_080130

Location (UCSC)

Chr 2: 174.35 – 174.4 Mb

Chr 2: 73.11 – 73.14 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Corepressor of RBPJ and splicing regulator is a protein that in humans is encoded by the CIRSR gene (previously CIR1).

Interactions

CIR (gene) has been shown to interact with SNW1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138433 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041777 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (Feb 2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing". Experimental Cell Research. 303 (2): 375–87. doi:10.1016/j.yexcr.2004.10.012. PMID 15652350.
↑ Zhang J, Chen H, Weinmaster G, Hayward SD (Mar 2001). "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC". Journal of Virology. 75 (6): 2946–56. doi:10.1128/JVI.75.6.2946-2956.2001. PMC 115921. PMID 11222720.
↑ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
↑ "Entrez Gene: CIR CBF1 interacting corepressor".
↑ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367.

External links

Human CIR1 genome location and CIR1 gene details page in the UCSC Genome Browser.

Further reading

DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP (Jan 1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system". Molecular and Cellular Biology. 7 (1): 379–87. doi:10.1128/mcb.7.1.379. PMC 365079. PMID 3031469.
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
Krithivas A, Young DB, Liao G, Greene D, Hayward SD (Oct 2000). "Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells". Journal of Virology. 74 (20): 9637–45. doi:10.1128/JVI.74.20.9637-9645.2000. PMC 112396. PMID 11000236.
Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–32. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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