CLIP1

CLIP1

Identifiers

CLIP1, CLIP, CLIP-170, CLIP170, CYLN1, RSN, CAP-Gly domain containing linker protein 1

External IDs

OMIM: 179838; MGI: 1928401; GeneCards: CLIP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CP5, 2CP6, 2E3H, 2E3I, 2E4H, 2HQH, 2QK0, 3E2U, 3RDV

Gene location (Human)

Chr.	Chromosome 12 (human)

Band	12q24.31	Start	122,271,432 bp
Band	12q24.31	End	122,422,669 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 F	Start	123,577,795 bp
Band	5\|5 F	End	123,684,618 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

biceps brachii

buccal mucosa cell

Skeletal muscle tissue of rectus abdominis

Skeletal muscle tissue of biceps brachii

gastrocnemius muscle

muscle of thigh

tendon of biceps brachii

tail of epididymis

gingival epithelium

amniotic fluid

Top expressed in

vastus lateralis muscle

muscle of thigh

triceps brachii muscle

temporal muscle

medial head of gastrocnemius muscle

sternocleidomastoid muscle

digastric muscle

tibialis anterior muscle

soleus muscle

lobe of cerebellum

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein homodimerization activity microtubule binding microtubule plus-end binding metal ion binding tubulin binding protein binding zinc ion binding identical protein binding
Cellular component	cytosol endosome centrosome cell projection membrane microtubule cytoskeleton ruffle microtubule plus-end macropinosome cytoplasmic microtubule microtubule cytoskeleton intermediate filament cytoplasmic vesicle membrane cytoplasmic vesicle kinetochore nuclear envelope cytoplasm
Biological process	microtubule bundle formation positive regulation of microtubule polymerization protein transport into plasma membrane raft mitotic cell cycle
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


6249


56430


ENSG00000130779


ENSMUSG00000049550


P30622


Q922J3

RefSeq (mRNA)


NM_001247997 NM_002956 NM_198240 NM_001389291

NM_001291229 NM_019765 NM_001347468 NM_001359220 NM_001359221
NM_001359222 NM_001359223 NM_001359224

RefSeq (protein)


NP_001234926 NP_002947 NP_937883

NP_001278158 NP_001334397 NP_062739 NP_001346149 NP_001346150
NP_001346151 NP_001346152 NP_001346153

Location (UCSC)

Chr 12: 122.27 – 122.42 Mb

Chr 5: 123.58 – 123.68 Mb

PubMed search

View/Edit Human

View/Edit Mouse

CAP-Gly domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.

Interactions

CLIP1 has been shown to interact with IQGAP1, Mammalian target of rapamycin and PAFAH1B1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130779 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049550 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1".
↑ Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell. 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184. S2CID 15158637.
↑ Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
↑ Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.

External links

Human CLIP1 genome location and CLIP1 gene details page in the UCSC Genome Browser.

Further reading

Galjart N (Jun 2005). "CLIPs and CLASPs and cellular dynamics". Nature Reviews Molecular Cell Biology. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712. S2CID 23216754.
Pierre P, Scheel J, Rickard JE, Kreis TE (Sep 1992). "CLIP-170 links endocytic vesicles to microtubules". Cell. 70 (6): 887–900. doi:10.1016/0092-8674(92)90240-D. PMID 1356075. S2CID 41119165.
Bilbe G, Delabie J, Brüggen J, Richener H, Asselbergs FA, Cerletti N, Sorg C, Odink K, Tarcsay L, Wiesendanger W (Jun 1992). "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease". The EMBO Journal. 11 (6): 2103–13. doi:10.1002/j.1460-2075.1992.tb05269.x. PMC 556677. PMID 1600942.
Pierre P, Pepperkok R, Kreis TE (Jul 1994). "Molecular characterization of two functional domains of CLIP-170 in vivo". Journal of Cell Science. 107 (7): 1909–20. doi:10.1242/jcs.107.7.1909. PMID 7983157.
Hilliker C, Delabie J, Speleman F, Bilbe G, Bruggen J, Van Leuven F, Van den Berghe H (1993). "Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus". Cytogenetics and Cell Genetics. 65 (3): 172–6. doi:10.1159/000133625. PMID 8222754.
Griparic L, Keller TC (Oct 1998). "Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1405 (1–3): 35–46. doi:10.1016/S0167-4889(98)00096-2. PMID 9784600.
Perez F, Diamantopoulos GS, Stalder R, Kreis TE (Feb 1999). "CLIP-170 highlights growing microtubule ends in vivo". Cell. 96 (4): 517–27. doi:10.1016/S0092-8674(00)80656-X. PMID 10052454. S2CID 18082011.
Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N (Mar 2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329. S2CID 14443149.
Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.
Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ (Mar 2002). "The cytoplasmic linker protein CLIP-170 is a human autoantigen". Clinical and Experimental Immunology. 127 (3): 533–8. doi:10.1046/j.1365-2249.2002.01756.x. PMC 1906301. PMID 11966772.
Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell. 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184. S2CID 15158637.
Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
Sahin U, Neumann F, Tureci O, Schmits R, Perez F, Pfreundschuh M (Dec 2002). "Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells". Blood. 100 (12): 4139–45. doi:10.1182/blood.V100.12.4139. PMID 12433698.
Goodson HV, Skube SB, Stalder R, Valetti C, Kreis TE, Morrison EE, Schroer TA (Jul 2003). "CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms". Cell Motility and the Cytoskeleton. 55 (3): 156–73. doi:10.1002/cm.10114. PMID 12789661.
Ho SM, Lau KM, Mok SC, Syed V (Jul 2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene. 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K (Dec 2004). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration". Developmental Cell. 7 (6): 871–83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.

v t e PDB gallery
2cp5: Solution structure of the 1st CAP-Gly domain in human CLIP-170/restin 2cp6: Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin 2cp7: Solution structure of the 1st CAP-Gly domain in mouse CLIP-170/restin

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