CNNM2

CNNM2
Identifiers
Aliases	CNNM2, ACDP2, HOMG6, HOMGSMR, cyclin and CBS domain divalent metal cation transport mediator 2
External IDs	OMIM: 607803; MGI: 2151054; GeneCards: CNNM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IY0, 4IY2, 4IY4, 4IYS
Gene location (Human)
Chr.	Chromosome 10 (human)
End	103,090,222 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,868,631 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right adrenal gland; ; sural nerve; ; right adrenal cortex; ; Epithelium of choroid plexus; ; left adrenal gland; ; left adrenal cortex; ; popliteal artery; ; tibial arteries; ; middle temporal gyrus;
	Top expressed in
	zygote; ; habenula; ; secondary oocyte; ; primary oocyte; ; right kidney; ; brown adipose tissue; ; primary visual cortex; ; superior frontal gyrus; ; proximal tubule; ; lumbar subsegment of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; magnesium ion transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; membrane; intracellular membrane-bounded organelle;
Biological process	magnesium ion transport; ion transport; magnesium ion homeostasis; magnesium ion transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54805
	94219
	ENSG00000148842
	ENSMUSG00000064105
	Q9H8M5
	Q3TWN3
	NM_017649; NM_199076; NM_199077
	NM_001102471; NM_033569
	NP_060119; NP_951058; NP_951059
	NP_001095941; NP_291047
	Wikidata
View/Edit Human	View/Edit Mouse

Metal transporter CNNM2 is a protein in humans that is encoded by the gene CNNM2. This protein is also called Cyclin M2, but it has no cyclin-like function in the body.

This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family (CNNM1, CNNM2, CNNM3 and CNNM4) contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

1 2 3 GRCh38: Ensembl release 89: ENSG00000148842 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000064105 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 "Entrez Gene: Cyclin M2". Retrieved 2013-02-23.
↑ "Metal transporter CNNM2". UniProt consortium. Retrieved 2026-11-04.

CNNM2

References

Further reading