COG1

COG1
Identifiers
Aliases	COG1, CDG2G, LDLB, component of oligomeric golgi complex 1
External IDs	OMIM: 606973; MGI: 1333873; GeneCards: COG1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	73,208,507 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	113,557,880 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; apex of heart; ; right frontal lobe; ; anterior pituitary; ; Brodmann area 9; ; nucleus accumbens; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; muscle of thigh;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; motor neuron; ; substantia nigra; ; islet of Langerhans; ; seminiferous tubule; ; Paneth cell; ; right ventricle; ; paraventricular nucleus of hypothalamus; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi membrane; Golgi apparatus; membrane; trans-Golgi network membrane; Golgi transport complex;
Biological process	protein transport; endoplasmic reticulum to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; Golgi organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9382
	16834
	ENSG00000166685
	ENSMUSG00000018661
	Q8WTW3
	Q9Z160
	NM_018714
	NM_013581
	NP_061184
	NP_038609
	Wikidata
View/Edit Human	View/Edit Mouse

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.

Interactions

COG1 has been shown to interact with COG4 and COG3.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166685 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018661 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex". Proc Natl Acad Sci U S A. 96 (3): 915–20. Bibcode:1999PNAS...96..915C. doi:10.1073/pnas.96.3.915. PMC 15325. PMID 9927668.
1 2 "Entrez Gene: COG1 component of oligomeric golgi complex 1".
↑ Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23). United States: 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
↑ Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24). United States: 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.

External links

GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
Human COG1 genome location and COG1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166685 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018661 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9927668-5] Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex". Proc Natl Acad Sci U S A. 96 (3): 915–20. Bibcode:1999PNAS...96..915C. doi:10.1073/pnas.96.3.915. PMC 15325. PMID 9927668.

[entrez-6] 1 2 "Entrez Gene: COG1 component of oligomeric golgi complex 1".

[pmid15047703-7] Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23). United States: 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.

[pmid11929878-8] Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24). United States: 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.

COG1

Interactions

References

Further reading

External links