CORO1B

CORO1B
Identifiers
Aliases	CORO1B, CORONIN-2, coronin 1B
External IDs	OMIM: 609849; MGI: 1345963; GeneCards: CORO1B
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,204,034 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; body of stomach; ; minor salivary glands; ; right uterine tube; ; gallbladder; ; left lobe of thyroid gland; ; monocyte; ; spleen; ; right coronary artery; ; left uterine tube;
	Top expressed in
	ileum; ; jejunum; ; colon; ; granulocyte; ; adrenal gland; ; white adipose tissue; ; duodenum; ; thymus; ; spleen; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	Arp2/3 complex binding; actin filament binding; protein binding; identical protein binding; actin binding; cadherin binding;
Cellular component	cytoplasm; cytosol; focal adhesion; plasma membrane; stress fiber; cell leading edge; actin filament; perinuclear region of cytoplasm; extracellular exosome; cytoskeleton; cell periphery; lamellipodium;
Biological process	positive regulation of lamellipodium morphogenesis; ruffle organization; wound healing; actin filament branching; cellular response to platelet-derived growth factor stimulus; regulation of Arp2/3 complex-mediated actin nucleation; negative regulation of Arp2/3 complex-mediated actin nucleation; actin filament bundle assembly; protein localization to cell leading edge; negative regulation of smooth muscle cell chemotaxis; endothelial cell chemotaxis; cell migration; actin cytoskeleton organization; actin filament organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry
	57175
	23789
	n/a
	ENSMUSG00000024835
	Q9BR76
	Q9WUM3
	NM_020441; NM_001018070
	NM_011778
	NP_001018080; NP_065174
	NP_035908
	Wikidata
View/Edit Human	View/Edit Mouse

Coronin, actin binding protein, 1B also known as CORO1B is a protein which in humans is encoded by the CORO1B gene. Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility.

Function

A mammalian coronin enriches at the leading edge of migrating cells. Studies related to this protein are as follows:

Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.
F-actin binding is essential for coronin 1B function in vivo.
Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.
Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024835 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (September 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.
1 2 Cai L, Holoweckyj N, Schaller MD, Bear JE (September 2005). "Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility". J. Biol. Chem. 280 (36): 31913–23. doi:10.1074/jbc.M504146200. PMID 16027158.
↑ "Entrez Gene: CORO1B coronin, actin binding protein, 1B".
↑ Cai L, Makhov AM, Schafer DA, Bear JE (September 2008). "Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia". Cell. 134 (5): 828–42. doi:10.1016/j.cell.2008.06.054. PMC 2570342. PMID 18775315.
↑ Cai L, Makhov AM, Bear JE (May 2007). "F-actin binding is essential for coronin 1B function in vivo". J. Cell Sci. 120 (Pt 10): 1779–90. doi:10.1242/jcs.007641. PMID 17456547.
↑ Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE (March 2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge". Cell. 128 (5): 915–29. doi:10.1016/j.cell.2007.01.031. PMC 2630706. PMID 17350576.
↑ Di Giovanni S, De Biase A, Yakovlev A, Finn T, Beers J, Hoffman EP, Faden AI (January 2005). "In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury". J. Biol. Chem. 280 (3): 2084–91. doi:10.1074/jbc.M411975200. PMID 15522871.
↑ Parente JA, Chen X, Zhou C, Petropoulos AC, Chew CS (January 1999). "Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway". J. Biol. Chem. 274 (5): 3017–25. doi:10.1074/jbc.274.5.3017. PMID 9915840.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024835 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9778037-4] Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (September 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.

[pmid16027158-5] 1 2 Cai L, Holoweckyj N, Schaller MD, Bear JE (September 2005). "Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility". J. Biol. Chem. 280 (36): 31913–23. doi:10.1074/jbc.M504146200. PMID 16027158.

[entrez-6] "Entrez Gene: CORO1B coronin, actin binding protein, 1B".

[pmid18775315-7] Cai L, Makhov AM, Schafer DA, Bear JE (September 2008). "Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia". Cell. 134 (5): 828–42. doi:10.1016/j.cell.2008.06.054. PMC 2570342. PMID 18775315.

[pmid17456547-8] Cai L, Makhov AM, Bear JE (May 2007). "F-actin binding is essential for coronin 1B function in vivo". J. Cell Sci. 120 (Pt 10): 1779–90. doi:10.1242/jcs.007641. PMID 17456547.

[pmid17350576-9] Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE (March 2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge". Cell. 128 (5): 915–29. doi:10.1016/j.cell.2007.01.031. PMC 2630706. PMID 17350576.

[pmid15522871-10] Di Giovanni S, De Biase A, Yakovlev A, Finn T, Beers J, Hoffman EP, Faden AI (January 2005). "In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury". J. Biol. Chem. 280 (3): 2084–91. doi:10.1074/jbc.M411975200. PMID 15522871.

[pmid9915840-11] Parente JA, Chen X, Zhou C, Petropoulos AC, Chew CS (January 1999). "Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway". J. Biol. Chem. 274 (5): 3017–25. doi:10.1074/jbc.274.5.3017. PMID 9915840.