COX6B2

COX6B2
Identifiers
AliasesCOX6B2, COXVIB2, CT59, cytochrome c oxidase subunit 6B2
External IDsOMIM: 618127; MGI: 3044182; GeneCards: COX6B2
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

125965

333182

Ensembl

ENSG00000160471

ENSMUSG00000051811

UniProt

Q6YFQ2

Q80ZN9

RefSeq (mRNA)

NM_144613

NM_001289848
NM_001289849
NM_001289850
NM_183405
NM_183406

RefSeq (protein)

NP_653214
NP_001356727
NP_001356728
NP_001356729

NP_001276777
NP_001276778
NP_001276779
NP_899664
NP_899665

Location (UCSC)Chr 19: 55.35 – 55.35 MbChr 7: 4.75 – 4.76 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome c oxidase subunit VIb polypeptide 2 is a protein that in humans is encoded by the COX6B2 gene. Cytochrome c oxidase 6B2 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.

Structure

The COX6B2 gene, located on the q arm of chromosome 19 in position 13.42, contains 5 exons and is 5,113 base pairs in length. The protein encoded by the COX6B2 gene weighs 11 kDa and is composed of 88 amino acids. The protein is a subunit of Complex IV, a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.

Function

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane to drive ATP synthesis via protonmotive force. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.

Summary reaction:

4 Fe2+-cytochrome c + 8 H+in + O2 → 4 Fe3+-cytochrome c + 2 H2O + 4 H+out

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160471 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051811 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 "Entrez Gene: Cytochrome c oxidase subunit VIb polypeptide 2".
  6. ↑ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, et al. (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–1053. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
  7. ↑ "Cytochrome c oxidase subunit VIb polypeptide 2". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 2018-07-19. Retrieved 2018-07-18.
  8. ↑ Voet D, Voet JG, Pratt CW (2013). "Chapter 18". Fundamentals of biochemistry: life at the molecular level (4th ed.). Hoboken, NJ: Wiley. pp. 581–620. ISBN 978-0-470-54784-7.

Further reading

  • Taanman JW, Schrage C, Ponne NJ, Das AT, Bolhuis PA, de Vries H, et al. (September 1990). "Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues". Gene. 93 (2): 285–291. doi:10.1016/0378-1119(90)90237-l. PMID 2172092.
  • Hüttemann M, Jaradat S, Grossman LI (September 2003). "Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c?". Molecular Reproduction and Development. 66 (1): 8–16. doi:10.1002/mrd.10327. PMID 12874793. S2CID 45002095.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.