CRIPT

CRIPT

Identifiers

CRIPT, SSMDF, HSPC139, CXXC repeat containing interactor of PDZ3 domain

External IDs

OMIM: 604594; MGI: 1929655; GeneCards: CRIPT

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2p21	Start	46,616,416 bp
Band	2p21	End	46,630,176 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 E4	Start	87,332,978 bp
Band	17\|17 E4	End	87,343,238 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

endothelial cell

corpus epididymis

caput epididymis

tail of epididymis

cerebellar vermis

internal globus pallidus

superficial temporal artery

visceral pleura

buccal mucosa cell

trabecular bone

Top expressed in

zygote

spermatocyte

spermatid

medial ganglionic eminence

endocardial cushion

Epithelium of choroid plexus

seminal vesicula

blood

facial motor nucleus

anterior horn of spinal cord

More reference expression data


More reference expression data

Gene ontology
Molecular function	microtubule binding scaffold protein binding PDZ domain binding protein binding protein-containing complex binding
Cellular component	cytoplasm dendritic shaft cell junction soma dendritic spine dendrite cell projection synapse nucleolus postsynaptic density nucleus fibrillar center
Biological process	regulation of postsynaptic density protein 95 clustering protein localization to microtubule cytoplasmic microtubule organization establishment of protein localization
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9419


56724


ENSG00000119878


ENSMUSG00000024146


Q9P021


O70333

RefSeq (mRNA)


NM_014171


NM_019936

RefSeq (protein)


NP_054890


NP_064320

Location (UCSC)

Chr 2: 46.62 – 46.63 Mb

Chr 17: 87.33 – 87.34 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.

Interactions

CRIPT has been shown to interact with DLG3.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119878 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024146 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). "The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins". J Biochem. 138 (2): 177–82. doi:10.1093/jb/mvi107. PMID 16091592.
↑ Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). "The PDZ1 domain of SAP90. Characterization of structure and binding". J Biol Chem. 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.
↑ Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95". Nat Neurosci. 2 (12): 1063–9. doi:10.1038/15990. PMID 10570482. S2CID 8145832.
↑ Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762. S2CID 16068361.
↑ "Entrez Gene: CRIPT cysteine-rich PDZ-binding protein".
↑ Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24). United States: 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501.

Further reading

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Lim IA, Hall DD, Hell JW (2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.
Cai C, Coleman SK, Niemi K, Keinänen K (2002). "Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif". J. Biol. Chem. 277 (35): 31484–90. doi:10.1074/jbc.M204354200. PMID 12070168.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). "Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays". J. Am. Chem. Soc. 128 (17): 5913–22. doi:10.1021/ja060943h. PMC 2533859. PMID 16637659.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

External links

Human CRIPT genome location and CRIPT gene details page in the UCSC Genome Browser.

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