CTR9

CTR9
Identifiers
Aliases	CTR9, SH2BP1, TSBP, p150, p150TSP, CTR9 homolog, Paf1/RNA polymerase II complex component
External IDs	OMIM: 609366; MGI: 109345; GeneCards: CTR9
Gene location (Human)
Chr.	Chromosome 11 (human)
End	10,801,625 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	110,655,584 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; epithelium of nasopharynx; ; palpebral conjunctiva; ; bronchial epithelial cell; ; germinal epithelium; ; retinal pigment epithelium; ; caput epididymis; ; oral cavity; ; jejunal mucosa; ; tail of epididymis;
	Top expressed in
	Rostral migratory stream; ; neural layer of retina; ; spermatocyte; ; transitional epithelium of urinary bladder; ; tail of embryo; ; gastrula; ; uterus; ; spermatid; ; genital tubercle; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II complex binding; SH2 domain binding; protein binding;
Cellular component	nuclear speck; nucleus; nucleoplasm; Cdc73/Paf1 complex;
Biological process	histone monoubiquitination; receptor signaling pathway via JAK-STAT; negative regulation of mRNA polyadenylation; regulation of transcription, DNA-templated; histone H3-K4 trimethylation; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; transcription, DNA-templated; stem cell population maintenance; interleukin-6-mediated signaling pathway; endodermal cell fate commitment; positive regulation of histone H3-K4 methylation; inner cell mass cell differentiation; trophectodermal cell differentiation; positive regulation of histone H3-K79 methylation; blastocyst growth; histone H2B ubiquitination; positive regulation of histone H2B ubiquitination; cellular response to lipopolysaccharide; negative regulation of myeloid cell differentiation; regulation of genetic imprinting; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; protein ubiquitination; histone modification; regulation of histone H3-K4 methylation; blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9646
	22083
	ENSG00000198730
	ENSMUSG00000005609
	Q6PD62
	Q62018
	NM_014633; NM_001346279
	NM_009431
	NP_001333208; NP_055448
	NP_033457
	Wikidata
View/Edit Human	View/Edit Mouse

RNA polymerase-associated protein CTR9 homolog is an enzyme that in humans is encoded by the CTR9 gene. This protein is a component of the PAF1 complex, which is involved in regulating DNA to RNA transcription by RNA polymerase II.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198730 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005609 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
↑ Malek SN, Yang CH, Earnshaw WC, Kozak CA, Desiderio S (Jul 1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains". J Biol Chem. 271 (12): 6952–62. doi:10.1074/jbc.271.12.6952. PMID 8636124.
1 2 "Entrez Gene: CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)".

External links

Human CTR9 genome location and CTR9 gene details page in the UCSC Genome Browser.

Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198730 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005609 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8590280-5] Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.

[pmid8636124-6] Malek SN, Yang CH, Earnshaw WC, Kozak CA, Desiderio S (Jul 1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains". J Biol Chem. 271 (12): 6952–62. doi:10.1074/jbc.271.12.6952. PMID 8636124.

[entrez-7] 1 2 "Entrez Gene: CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)".

CTR9

References

External links

Further reading