Chymotrypsinogen B2

CTRB2
Identifiers
Aliases	CTRB2, chymotrypsinogen B2
External IDs	MGI: 88559; GeneCards: CTRB2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 16 (human)
End	75,207,161 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	112,417,642 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; gonad; ; fundus; ; right coronary artery; ; duodenum; ; ectocervix; ; left uterine tube; ; placenta; ; canal of the cervix;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; migratory enteric neural crest cell; ; cardiac muscle tissue of left ventricle; ; plantaris muscle; ; extensor digitorum longus muscle; ; interventricular septum; ; duodenum; ; corneal stroma; ; sexually immature organism;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; serine-type endopeptidase activity; serine-type peptidase activity;
Cellular component	extracellular region; extracellular space;
Biological process	digestion; cobalamin metabolic process; extracellular matrix disassembly; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	440387
	66473
	ENSG00000168928; ENSG00000284810
	ENSMUSG00000031957
	Q6GPI1
	Q9CR35
	NM_001025200
	NM_025583
	NP_001020371
	NP_079859
	Wikidata
View/Edit Human	View/Edit Mouse

Chymotrypsinogen B2 is a protein that in humans is encoded by the CTRB2 gene. Chymotrypsinogen B2 is an inactive precursor enzyme (or zymogen) for an active enzyme, which is sometimes called chymotrypsin B2. This enzyme is an isozyme of chymotrypsin that participates in the digestion and breakdown of proteins. The inactive protein is produced by the acinar cells in the pancreas, then secreted into the small intestines where it is cleaved and activated by trypsin, another digestive enzyme. After cleaving, Chymotrypsin B2 is composed of 3 peptide chains which remain connected via disulfide bridges.

References

1 2 3 ENSG00000284810 GRCh38: Ensembl release 89: ENSG00000168928, ENSG00000284810 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031957 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 "Entrez Gene: Chymotrypsinogen B2". Retrieved 2018-04-17.
↑ Gonzalez-Titos A, Hernandez-Camarero P, Barungi S, Marchal JA, Kenyon J, Peran M (2021-12-02). "Trypsinogen and chymotrypsinogen: potent anti-tumor agents" (PDF). Expert Opinion on Biological Therapy. 21 (12): 1609–21. doi:10.1080/14712598.2021.1922666.
↑ Pandol SJ (2010). "Anatomy". The Exocrine Pancreas. Morgan & Claypool Life Science.
↑ "Q6GPI1 · CTRB2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-01.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000284810 GRCh38: Ensembl release 89: ENSG00000168928, ENSG00000284810 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031957 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 4 "Entrez Gene: Chymotrypsinogen B2". Retrieved 2018-04-17.

[6] Gonzalez-Titos A, Hernandez-Camarero P, Barungi S, Marchal JA, Kenyon J, Peran M (2021-12-02). "Trypsinogen and chymotrypsinogen: potent anti-tumor agents" (PDF). Expert Opinion on Biological Therapy. 21 (12): 1609–21. doi:10.1080/14712598.2021.1922666.

[pandol2010-7] Pandol SJ (2010). "Anatomy". The Exocrine Pancreas. Morgan & Claypool Life Science.

[8] "Q6GPI1 · CTRB2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-01.

Chymotrypsinogen B2

See also

References