CYB5R4

CYB5R4
Identifiers
Aliases	CYB5R4, NCB5OR, cb5/cb5R, dJ676J13.1, cytochrome b5 reductase 4
External IDs	OMIM: 608343; MGI: 2386848; GeneCards: CYB5R4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LF5
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	83,967,423 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	86,959,827 bp
RNA expression pattern
	Top expressed in
	monocyte; ; sperm; ; blood; ; bone marrow; ; granulocyte; ; bone marrow cell; ; right testis; ; left testis; ; appendix; ; islet of Langerhans;
	Top expressed in
	granulocyte; ; ileum; ; ganglionic eminence; ; jejunum; ; zygote; ; quadriceps femoris muscle; ; duodenum; ; neural tube; ; tail of embryo; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; NAD(P)H oxidase H2O2-forming activity; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; heme binding; metal ion binding; cytochrome-b5 reductase activity, acting on NAD(P)H;
Cellular component	perinuclear region of cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	response to antibiotic; insulin secretion; detection of oxygen; generation of precursor metabolites and energy; glucose homeostasis; superoxide metabolic process; cell development; bicarbonate transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51167
	266690
	ENSG00000065615
	ENSMUSG00000032872
	Q7L1T6
	Q3TDX8
	NM_016230
	NM_024195; NM_001359962
	NP_057314
	NP_077157; NP_001346891
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000065615 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032872 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Jan 2000). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc Natl Acad Sci U S A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.
1 2 "Entrez Gene: CYB5R4 cytochrome b5 reductase 4".

External links

Human CYB5R4 genome location and CYB5R4 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000065615 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032872 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10611283-5] Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Jan 2000). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc Natl Acad Sci U S A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.

[entrez-6] 1 2 "Entrez Gene: CYB5R4 cytochrome b5 reductase 4".

CYB5R4

References

Further reading

External links