CYRI-A

CYRIA
Identifiers
Aliases	CYRIA, family with sequence similarity 49 member A, FAM49A, CYFIP related Rac1 interactor A
External IDs	MGI: 1261783; GeneCards: CYRIA
Gene location (Human)
Chr.	Chromosome 2 (human)
End	16,666,331 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	12,430,966 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; monocyte; ; middle temporal gyrus; ; superior frontal gyrus; ; prefrontal cortex; ; entorhinal cortex; ; dorsolateral prefrontal cortex; ; orbitofrontal cortex; ; primary visual cortex; ; lateral nuclear group of thalamus;
	Top expressed in
	olfactory tubercle; ; piriform cortex; ; cingulate gyrus; ; primary motor cortex; ; subiculum; ; anterior amygdaloid area; ; visual cortex; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; nucleus accumbens;
	More reference expression data
	; ;
	More reference expression data
Orthologs
Databases	NCBI: entry; OMA: entry
	81553
	76820
	ENSG00000197872
	ENSMUSG00000020589
	Q9H0Q0
	Q8BHZ0
	NM_030797
	NM_001146119; NM_029758; NM_001364432
	NP_110424
	NP_001139591; NP_084034; NP_001351361
	Wikidata
View/Edit Human	View/Edit Mouse

CYFIP-related Rac1 interactor A (or CYRI-A) is a protein which in humans is encoded by the CYRIA gene (previously FAM49A).

Gene

CYRIA is located on human chromosome 2, at 2p24.3. It has 1512 base pairs in the reference sequence mRNA transcript.

Protein

The CYRI-A is a 323 amino acid protein. The protein contains two domains: Residues 15-319 comprise the "Domain of Unknown Function 1394" (DUF1394, Pfam PF07159). Residues 67->281 comprise the "Cytoplasmic Fragile X Interacting Superfamily" region.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197872 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020589 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FAM49A family with sequence similarity 49, member A".
↑ "Nucleotide - family with sequence similarity 49, member A [Homo sapiens]". Nucleotide. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.
↑ "Protein - family with sequence similarity 49, member A [Homo sapiens]". Protein. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197872 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020589 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FAM49A family with sequence similarity 49, member A".

[urlNucleotide_-_family_with_sequence_similarity_49,_member_A_[Homo...-6] "Nucleotide - family with sequence similarity 49, member A [Homo sapiens]". Nucleotide. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.

[urlProtein_-_family_with_sequence_similarity_49,_member_A_[Homo...-7] "Protein - family with sequence similarity 49, member A [Homo sapiens]". Protein. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.

CYRI-A

Gene

Protein

References

Further reading