Calphostin

The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.

Calpohostin R1 R2
Calphostin A Bz Bz
Calphostin B Bz H
Calphostin C Bz 4-(HO)Bz
Calphostin D H H
Calphostin I 4-(HO)Bz 4-(HO)Bz

Calphostin C

Calphostin C is a potent inhibitor of protein kinase C (PKC).

References

  1. 1 2 3 4 Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". Journal of Antibiotics. 42 (10): 1470–1474. doi:10.7164/antibiotics.42.1470. PMID 2478514.
  2. 1 2 3 Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". Journal of Antibiotics. 42 (10): 1475–1481. doi:10.7164/antibiotics.42.1475. PMID 2478515.
  3. 1 2 "Calphostin C". Biomol GmbH. Retrieved 11 October 2024.