Acting and presenting
Daddo's first television role was as host of a children's show called Off the Dish. He soon hosted The Cameron Daddo Cartoon Show, before replacing Greg Evans as the host of dating game show Perfect Match Australia from 1987 to 1988. He was 21 years old, which made him the youngest host of an Australian game show.
Following his hosting roles, Daddo turned his hand to acting, with a role in 1989 miniseries, The Heroes. The same year, he scored the lead role of Huck Finn in the stage musical Big River. Daddo's performance won him a Mo Award, and a Variety Theatre Performer of the Year accolade. The production ran for 15 months with over 1,000 shows.
Daddo next appeared in the 1990 telemovie series Bony, playing a detective and the fictional grandson of Napoleon Bonaparte, the protagonist in 29 detective novels by Arthur Upfield. His character was said to be a white man raised by Aboriginal people. An Aboriginal uncle serves as his mentor. The role won him a People's Choice Award for Best Actor in a Dramatic Series.
In 1992, Daddo won the Logie Award for Most Popular Actor in a Telemovie or Miniseries, for his appearance in the miniseries Golden Fiddles. He won again in 1993 for his portrayal of bicycle champion Don Walker in Tracks of Glory.
Daddo often found himself making it to the final two for potentially career-defining roles – including the lead in Baz Luhrmann's 1992 film Strictly Ballroom, which ultimately went to Paul Mercurio – but missing out. Wanting to further his career, he moved to Los Angeles in 1992 to pursue acting in Hollywood. He was cast in the role of photographer Brian Peterson in the Aaron Spelling Melrose Place spin-off Models Inc., which was cancelled after the first season. He next made a one-off guest appearance in a 1993 episode of The Young Indiana Jones Chronicles.
In 1996, Daddo played Rollie Tyler in F/X: The Series, the character played by Bryan Brown in the film version. He also appeared in the PAX TV network's Hope Island from 1999 to 2000. In 2000, he appeared in Anne of Green Gables: The Continuing Story as American writer, Jack Garrison.
In 2002, Daddo played Darryl Wright, a lead guest character in the episode "Monk and the Earthquake" in the first season of television series Monk. He next appeared as Samuel Clemens in the 2003 television pilot Riverworld, based on the sci-fi novels of the same name. He also played the role of Quentin Cross in the second season of She Spies from 2003 to 2004.
Daddo also had roles in David Lynch's 2006 film Inland Empire, playing Devon Berk's manager and comedy film Big Momma's House 2. In 2007, he hosted the Mark Burnett reality show Pirate Master on CBS, and appeared in the movie Drifter. In 2009, he played the role of Vice President Mitchell Hayworth on 24. He also appeared in episodes of The Mentalist, Nikita, CSI and NCIS.
Daddo starred as the interviewer in an Australian adult romance feature film, SIX LOVERS, which finished production in 2010 and was released in 2012. In 2014, he appeared in the Australian Theatre Company's Los Angeles production of Holding the Man opposite Nate Jones, Roxane Wilson and Adam J. Yeend.
Daddo participated as the subject on a 2011 episode of Who Do You Think You Are?, travelling to the Channel Islands to trace his ancestry.
In 2012, Daddo returned to the Australian stage for the first time in 20 years as Professor Callahan in the Australian production of Legally Blonde. He was cast in the role of Captain Georg Von Trapp in the 2016 Australian tour of the London Palladium production of The Sound of Music opposite Amy Lehpamer in the role of Maria.
Daddo next participated in the 2018 second season of Filthy Rich and Homeless, an SBS documentary series where high-profile Australians hoping to enact positive change swapped their privileged lives to experience homeless life on the streets of Sydney.
From May to June 2020, Daddo appeared in Home and Away as Evan Slater, the estranged father of Ryder Jackson (played by Lukas Radovich).
In 2022, Daddo co-hosted the fifth season of the travel series Luxury Escapes. The same year, he appeared as a 'wildcard' contestant on the Australian series of Dancing with the Stars, but was eliminated in the first episode, when he failed to impress the judges with his tango, scoring 23 out of 40.
Daddo most recently appeared opposite Rebecca Gibney in Sydney Theatre Company's 2025 production of Circle Mirror Transformation.
Music
Daddo is also a musician, having played in the bands 'The Nearly Smooth Guys' (prior to his acting career) and 'Baby James'. His debut album as a solo artist, "A Long Goodbye", featured Keith Urban on back-up vocals and guitars and reached #2 on the Australian country music charts in 1992.
In 2012, Daddo released the album Ten Songs – and Change. He released another album, Songs from the Shed in 2016, featuring a song called “Steve McQueen”, after having stayed at actor McQueen's house in Palm Springs. In 2020, he released the EP Son and Moon, the title track of which was featured in the television series Home and Away, during his tenure on the show.
As of 2021, Daddo was fronting a new band, 'Cam Daddo and the Paisley Prophets', who perform around Sydney.
Daddo has also written a one-man musical, House Devil, Street Angel.
Radio
In October 2012, Daddo joined smoothfm as Sunday Mornings host in the 8am to 10am timeslot. In March 2013, Daddo became the host of Mellow Music, airing nightly, from 8pm to midnight, on smoothfm.
In 2022, Daddo collaborated with Nova to launch the podcast series So You Want to Make a TV Show with brother Andrew Daddo, which detailed the creative process behind making scripted television.
Daddo and his wife Alison Brahe have hosted Separate Bathrooms and Other Handy Marriage Tips since 2019, an Acast podcast in which they chat about the journey of their 30-year marriage. As of 2025, the podcast relaunched with Nova Podcasts under the new name of The Heart of It.
