Chlorphenesin

Chlorphenesin
Names
	IUPAC name 3-(4-Chlorophenoxy)propane-1,2-diol
	Other names Chlorphenesin
Identifiers
CAS Number	104-29-0;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:3642;
ChEMBL	ChEMBL388751;
ChemSpider	7411;
ECHA InfoCard	100.002.902
EC Number	203-192-6;
KEGG	C07928;
PubChem CID	7697;
UNII	I670DAL4SZ;
CompTox Dashboard (EPA)	DTXSID0049028 ;
	InChI InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2 Key: RLLPVAHKSCTKIL-UHFFFAOYSA-N;
	SMILES C1=CC(=CC=C1OCC(CO)O)Cl;
Properties
Chemical formula	C9H11ClO3
Molar mass	202.63 g·mol−1
Melting point	77 to 78 °C (171 to 172 °F; 350 to 351 K)
Solubility in water	10.4 g/L
log P	1.2
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H302, H315, H318, H319, H332, H335
Precautionary statements	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chlorphenesin is a synthetic chemical used as a preservative in certain cosmetics. Owing to its antifungal and antibacterial properties; it is classified as an antifungal for topical use by the WHO. The major adverse effect from this preservative on skin is allergic contact sensitivity. Systemic intoxication from transdermal use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.

References

↑ PubChem. "Chlorphenesin". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-07-15.
↑ ATC code D01AE07
↑ Brown R (May 1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118. S2CID 37580364.
↑ Burns DA (April 1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis. 14 (4): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223. S2CID 43810471.
↑ "FDA Warns Consumers Against Using Mommy's Bliss Nipple Cream Product can be harmful to nursing infants". Food and Drug Administration. Archived from the original on June 18, 2009.

[1] PubChem. "Chlorphenesin". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-07-15.

[2] ATC code D01AE07

[3] Brown R (May 1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118. S2CID 37580364.

[4] Burns DA (April 1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis. 14 (4): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223. S2CID 43810471.

[5] "FDA Warns Consumers Against Using Mommy's Bliss Nipple Cream Product can be harmful to nursing infants". Food and Drug Administration. Archived from the original on June 18, 2009.