Condensation domain

Available protein structures:
PDB	IPR001242 PF00668 (ECOD; PDBsum)
AlphaFold	IPR001242; PF00668;

Condensation
Condensation
	crystal structure of vibh, an nrps condensation enzyme
Identifiers
Symbol	Condensation
Pfam	PF00668
Pfam clan	CL0149
InterPro	IPR001242
SCOP2	1l5a / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	IPR001242 PF00668 (ECOD; PDBsum)
AlphaFold	IPR001242; PF00668;

In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.

References

↑ Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA (August 1998). "Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain". J. Biol. Chem. 273 (35): 22773–81. doi:10.1074/jbc.273.35.22773. PMID 9712910.

This article incorporates text from the public domain Pfam and InterPro: IPR001242

[pmid9712910-1] Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA (August 1998). "Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain". J. Biol. Chem. 273 (35): 22773–81. doi:10.1074/jbc.273.35.22773. PMID 9712910.