Cytoskeleton regulator RNA

CYTOR
Identifiers
Aliases	CYTOR, C2orf59, NCRNA00152, LINC00152, long intergenic non-protein coding RNA 152, cytoskeleton regulator RNA
External IDs	GeneCards: CYTOR
Gene location (Human)
Chr.	Chromosome 2 (human)
End	87,636,740 bp
RNA expression pattern
	Top expressed in
	bone marrow cell; ; monocyte; ; granulocyte; ; spleen; ; blood; ; epithelium of colon; ; subcutaneous adipose tissue; ; lymph node; ; islet of Langerhans; ; stromal cell of endometrium;
	n/a
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	112597
	n/a
	ENSG00000222041
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Cytoskeleton regulator RNA is a long non-coding RNA that in humans is encoded by the CYTOR gene.

CYTOR plays a role in breast cancer. It regulates genes involved in the EGFR/mammalian target of rapamycin pathway and is required for cell proliferation, cell migration, and cytoskeleton organization.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000222041 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Van Grembergen, Olivier (2016). "Portraying breast cancer with long non coding RNA". Science Advances. 2 (9) e1600220. Bibcode:2016SciA....2E0220V. doi:10.1126/sciadv.1600220. PMC 5010371. PMID 27617288.
↑ "Entrez Gene: Cytoskeleton regulator RNA". Archived from the original on 2016-10-01. Retrieved 2017-09-04.

Van Grembergen O, Bizet M, de Bony EJ, Calonne E, Putmans P, Brohée S, Olsen C, Guo M, Bontempi G, Sotiriou C, Defrance M, Fuks F (2016). "Portraying breast cancers with long noncoding RNAs". Sci Adv. 2 (9) e1600220. Bibcode:2016SciA....2E0220V. doi:10.1126/sciadv.1600220. PMC 5010371. PMID 27617288.
Pang Q, Ge J, Shao Y, Sun W, Song H, Xia T, Xiao B, Guo J (2014). "Increased expression of long intergenic non-coding RNA LINC00152 in gastric cancer and its clinical significance". Tumour Biol. 35 (6): 5441–7. doi:10.1007/s13277-014-1709-3. PMID 24523021. S2CID 1025668.
Tani H, Onuma Y, Ito Y, Torimura M (2014). "Long non-coding RNAs as surrogate indicators for chemical stress responses in human-induced pluripotent stem cells". PLOS ONE. 9 (8) e106282. Bibcode:2014PLoSO...9j6282T. doi:10.1371/journal.pone.0106282. PMC 4149554. PMID 25171338.
Zhao J, Liu Y, Zhang W, Zhou Z, Wu J, Cui P, Zhang Y, Huang G (2015). "Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer". Cell Cycle. 14 (19): 3112–23. doi:10.1080/15384101.2015.1078034. PMC 4825539. PMID 26237576.
Li J, Wang X, Tang J, Jiang R, Zhang W, Ji J, Sun B (2015). "HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma". Cell. Physiol. Biochem. 37 (2): 687–96. doi:10.1159/000430387. PMID 26356260.
Zhou J, Zhi X, Wang L, Wang W, Li Z, Tang J, Wang J, Zhang Q, Xu Z (2015). "Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway". J. Exp. Clin. Cancer Res. 34: 135. doi:10.1186/s13046-015-0250-6. PMC 4632266. PMID 26538117.
Ji J, Tang J, Deng L, Xie Y, Jiang R, Li G, Sun B (2015). "LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway". Oncotarget. 6 (40): 42813–24. doi:10.18632/oncotarget.5970. PMC 4767473. PMID 26540343.
Chen WM, Huang MD, Sun DP, Kong R, Xu TP, Xia R, Zhang EB, Shu YQ (2016). "Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer". Oncotarget. 7 (9): 9773–87. doi:10.18632/oncotarget.6949. PMC 4891083. PMID 26799422.
Yue B, Cai D, Liu C, Fang C, Yan D (2016). "Linc00152 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer". Mol. Ther. 24 (12): 2064–2077. doi:10.1038/mt.2016.180. PMC 5167786. PMID 27633443.
Hu HB, Jie HY, Zheng XX (2016). "Three Circulating LncRNA Predict Early Progress of Esophageal Squamous Cell Carcinoma". Cell. Physiol. Biochem. 40 (1–2): 117–125. doi:10.1159/000452529. PMID 27855375.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000222041 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Van Grembergen, Olivier (2016). "Portraying breast cancer with long non coding RNA". Science Advances. 2 (9) e1600220. Bibcode:2016SciA....2E0220V. doi:10.1126/sciadv.1600220. PMC 5010371. PMID 27617288.

[entrez-4] "Entrez Gene: Cytoskeleton regulator RNA". Archived from the original on 2016-10-01. Retrieved 2017-09-04.

Cytoskeleton regulator RNA

References

Further reading