The lied was written for bass voice in the key of B♭ major, but the key moves repeatedly through various major to minor tonalities, ending in C major. Goethe's dramatic declamation by Prometheus would be set again, with very different effect, by Hugo Wolf, "with his alternations of ariosos and recitatives, Schubert created a miniature oratorio", observes Edward F. Kravitt.
Among many other lieder by Schubert, Max Reger also created an orchestration for "Prometheus".
↑Wolf considered Schubert's "Ganymed" and "Prometheus" unsatisfactory, in part because "a truly Goethean spirit" could only be fulfilled in the "post-Wagnerian era", according to a Wolf letter to Emil Kaufmann, noted in Scott Messing, Schubert in the European Imagination: Fin-de-siècle Vienna, 2007, p. 192, note 57.