DAPP1

DAPP1

Identifiers

DAPP1, BAM32, dual adaptor of phosphotyrosine and 3-phosphoinositides, dual adaptor of phosphotyrosine and 3-phosphoinositides 1

External IDs

OMIM: 605768; MGI: 1347063; GeneCards: DAPP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FAO, 1FB8

Gene location (Human)

Chr.	Chromosome 4 (human)

Band	4q23	Start	99,816,827 bp
Band	4q23	End	99,870,190 bp

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)

Band	3\|3 G3	Start	137,636,768 bp
Band	3\|3 G3	End	137,687,306 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

amniotic fluid

epithelium of nasopharynx

monocyte

buccal mucosa cell

mucosa of paranasal sinus

oral cavity

epithelium of bronchus

bronchial epithelial cell

palpebral conjunctiva

sperm

Top expressed in

epithelium of small intestine

granulocyte

spermatocyte

seminiferous tubule

spermatid

blood

zygote

conjunctival fornix

tibiofemoral joint

bone marrow

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding phospholipid binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding PDZ domain binding
Cellular component	cytosol plasma membrane membrane cytoplasm
Biological process	protein dephosphorylation signal transduction
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


27071


26377


ENSG00000070190


ENSMUSG00000028159


Q9UN19


Q9QXT1

RefSeq (mRNA)


NM_001306151 NM_014395


NM_011932 NM_001310753

RefSeq (protein)


NP_001293080 NP_055210


NP_001297682 NP_036062

Location (UCSC)

Chr 4: 99.82 – 99.87 Mb

Chr 3: 137.64 – 137.69 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070190 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028159 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dowler S, Currie RA, Downes CP, Alessi DR (Oct 1999). "DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides". Biochem J. 342 (1): 7–12. doi:10.1042/0264-6021:3420007. PMC 1220429. PMID 10432293.
↑ "Entrez Gene: DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Marshall AJ, Niiro H, Lerner CG, et al. (2000). "A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase". J. Exp. Med. 191 (8): 1319–32. doi:10.1084/jem.191.8.1319. PMC 2193139. PMID 10770799.
Dowler S, Montalvo L, Cantrell D, et al. (2001). "Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase". Biochem. J. 349 (Pt 2): 605–10. doi:10.1042/0264-6021:3490605. PMC 1221184. PMID 10880360.
Ferguson KM, Kavran JM, Sankaran VG, et al. (2000). "Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains". Mol. Cell. 6 (2): 373–84. doi:10.1016/S1097-2765(00)00037-X. PMID 10983984.
Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Stephens LR, Anderson KE, Hawkins PT (2001). "Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines". J. Biol. Chem. 276 (46): 42767–73. doi:10.1074/jbc.M107194200. PMID 11524430.
Niiro H, Maeda A, Kurosaki T, Clark EA (2002). "The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival". J. Exp. Med. 195 (1): 143–9. doi:10.1084/jem.20011524. PMC 2196019. PMID 11781373.
Marshall AJ, Krahn AK, Ma K, et al. (2002). "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor". Mol. Cell. Biol. 22 (15): 5479–91. doi:10.1128/MCB.22.15.5479-5491.2002. PMC 133950. PMID 12101241.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Han A, Saijo K, Mecklenbräuker I, et al. (2003). "Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival". Immunity. 19 (4): 621–32. doi:10.1016/S1074-7613(03)00275-9. PMID 14563325.
Allam A, Niiro H, Clark EA, Marshall AJ (2004). "The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism". J. Biol. Chem. 279 (38): 39775–82. doi:10.1074/jbc.M403367200. PMID 15247305.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Niiro H, Allam A, Stoddart A, et al. (2004). "The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization". J. Immunol. 173 (9): 5601–9. doi:10.4049/jimmunol.173.9.5601. PMID 15494510.

v t e PDB gallery
1fao: STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE 1fb8: STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH

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