DHRS2

DHRS2

Identifiers

DHRS2, HEP27, SDR25C1, dehydrogenase/reductase (SDR family) member 2, dehydrogenase/reductase 2

External IDs

OMIM: 615194; MGI: 1918662; GeneCards: DHRS2

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q11.2	Start	23,630,115 bp
Band	14q11.2	End	23,645,639 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14 C3\|14	Start	55,459,464 bp
Band	14 C3\|14	End	55,478,892 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

mucosa of urinary bladder

islet of Langerhans

parotid gland

right lobe of liver

spleen

gonad

left ovary

nipple

amniotic fluid

placenta

Top expressed in

secondary oocyte

primary oocyte

zygote

embryo

embryo

lower lip

upper lip

trigeminal ganglion

sexually immature organism

esophagus

More reference expression data


More reference expression data

Gene ontology
Molecular function	oxidoreductase activity protein binding carbonyl reductase (NADPH) activity
Cellular component	cytoplasm mitochondrial matrix nuclear envelope mitochondrion nucleus
Biological process	cellular response to oxidative stress myeloid dendritic cell differentiation negative regulation of apoptotic process response to toxic substance C21-steroid hormone metabolic process negative regulation of cell population proliferation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10202


71412


ENSG00000100867


ENSMUSG00000022209


Q13268


n/a

RefSeq (mRNA)


NM_005794 NM_182908 NM_001318835


NM_027790

RefSeq (protein)


NP_001305764 NP_005785 NP_878912


n/a

Location (UCSC)

Chr 14: 23.63 – 23.65 Mb

Chr 14: 55.46 – 55.48 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Dehydrogenase/reductase SDR family member 2 is an enzyme that in humans is encoded by the DHRS2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100867 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022209 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gabrielli F, Donadel G, Bensi G, Heguy A, Melli M (Nov 1995). "A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family". Eur J Biochem. 232 (2): 473–7. doi:10.1111/j.1432-1033.1995.473zz.x. PMID 7556196.
↑ Heinz S, Krause SW, Gabrielli F, Wagner HM, Andreesen R, Rehli M (Apr 2002). "Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells". Genomics. 79 (4): 608–15. doi:10.1006/geno.2002.6743. PMID 11944995.
↑ Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U, Gabrielli F, Lardy H, Jornvall H, Oppermann U (Jun 2006). "Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue". Cell Mol Life Sci. 63 (10): 1205–13. doi:10.1007/s00018-006-6013-y. PMC 11136258. PMID 16685466. S2CID 24562253.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
↑ "Entrez Gene: DHRS2 dehydrogenase/reductase (SDR family) member 2".

Further reading

Donadel G, Garzelli C, Frank R, Gabrielli F (1991). "Identification of a novel nuclear protein synthesized in growth-arrested human hepatoblastoma HepG2 cells". Eur. J. Biochem. 195 (3): 723–9. doi:10.1111/j.1432-1033.1991.tb15759.x. PMID 1847869.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pellegrini S, Censini S, Guidotti S, et al. (2002). "A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product". Biochim. Biophys. Acta. 1574 (3): 215–22. doi:10.1016/s0167-4781(01)00323-2. PMID 11997086.
Bauer K, Zemlin M, Hummel M, et al. (2002). "Diversification of Ig heavy chain genes in human preterm neonates prematurely exposed to environmental antigens". J. Immunol. 169 (3): 1349–56. doi:10.4049/jimmunol.169.3.1349. PMID 12133958.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

DHRS2 human gene location in the UCSC Genome Browser.
DHRS2 human gene details in the UCSC Genome Browser.

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