DIPK2B

DIPK2B
Identifiers
Aliases	DIPK2B, 4930578C19Rik, DIA1R, EPQL1862, PRO3743, bA435K1.1, chromosome X open reading frame 36, CXorf36, divergent protein kinase domain 2B
External IDs	OMIM: 300959; MGI: 1923155; GeneCards: DIPK2B
Gene location (Human)
Chr.	X chromosome (human)
End	45,200,901 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	18,327,636 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; subcutaneous adipose tissue; ; body of uterus; ; smooth muscle tissue; ; tendon of biceps brachii; ; canal of the cervix; ; sural nerve; ; left uterine tube; ; right lobe of thyroid gland; ; left ventricle;
	Top expressed in
	embryo; ; muscle of thigh; ; esophagus; ; muscle tissue; ; proximal tubule; ; lip; ; skeletal muscle tissue; ; genital tubercle; ; right kidney; ; superior frontal gyrus;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	79742
	75905
	ENSG00000147113
	ENSMUSG00000037358
	Q9H7Y0
	Q8C3I9
	NM_024689; NM_176819
	NM_175228
	NP_078965; NP_789789
	NP_780437
	Wikidata
View/Edit Human	View/Edit Mouse

Divergent protein kinase domain 2B is a protein which in humans is encoded by the gene DIPK2B (previously CXorf36). This protein is most highly expressed in the placenta and fat tissues, and it is predicted that this protein is extracellular, but otherwise the function is not currently very well understood. A notable homolog is DIPK2A.

Gene

The location of the DIPK2B gene on chromosome X

It can be transcribed into 8 different transcript variants, which in turn can produce 6 different isoforms of the protein.

The genomic DNA is 52,529 base pairs long, while the longest mRNA that it produces is 4,735 bases long.

Gene Neighborhood

DIPK2B is closely surrounded by the following genes on chromosome X:

DUSP21
KDM6A
MIR222
TBX20

DIPK2B is also surrounded by two other genes on chromosome X that have been implicated in X-linked mental retardation.

Protein

The longest protein isoform that is produced by the DIPK2B gene is termed hypothetical protein LOC79742 isoform 1 and is 433 amino acids long.

Expression

DIPK2B is shown to be expressed ubiquitously at low levels in various tissues throughout the body. It is expressed highly in the ciliary ganglion, ovary, and uterus corpus. However, highest expression is seen in the trigeminal ganglion tissue.

Conservation

DIPK2B has one paralog in humans known as DIPK2A. Orthologs have been found in all mammals and through numerous eukaryotes. However, conservation of the full gene halts past this, most likely a result of duplication from the ancestral gene into DIPK2B and DIPK2A. The full list of organisms in which orthologs have been found is given below.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000147113 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037358 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "DIPK2B divergent protein kinase domain 2B". Retrieved 2026-07-31.
↑ Thiselton DL, McDowall J, Brandau O, Ramser J, d'Esposito F, Bhattacharya SS, Ross MT, Hardcastle AJ, Meindl A (April 2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
↑ "Q9H7Y0 · DIK2B_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-07-31.
↑ "NCBI AceView: CXorf36". Retrieved 2011-04-28.
↑ Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, O'Meara S, Latimer C, Dicks E, Menzies A, Stephens P, Blow M, Greenman C, Xue Y, Tyler-Smith C, Thompson D, Gray K, Andrews J, Barthorpe S, Buck G, Cole J, Dunmore R, Jones D, Maddison M, Mironenko T, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Teague J, Butler A, Jenkinson A, Jia M, Richardson D, Shepherd R, Wooster R, Tejada MI, Martinez F, Carvill G, Goliath R, de Brouwer AP, van Bokhoven H, Van Esch H, Chelly J, Raynaud M, Ropers HH, Abidi FE, Srivastava AK, Cox J, Luo Y, Mallya U, Moon J, Parnau J, Mohammed S, Tolmie JL, Shoubridge C, Corbett M, Gardner A, Haan E, Rujirabanjerd S, Shaw M, Vandeleur L, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR (May 2009). "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation". Nat. Genet. 41 (5): 535–43. doi:10.1038/ng.367. PMC 2872007. PMID 19377476.
↑ "NCBI Protein: hypothetical protein LOC79742 isoform 1". Retrieved May 10, 2011.
↑ "NCBI GEO Profiles: CXorf36". Retrieved May 10, 2011.
↑ "KEGG: C3orf58". Retrieved May 10, 2011.
↑ "NCBI BLAST". Retrieved May 9, 2011.

External links

Human DIPK2B genome location and DIPK2B gene details page in the UCSC Genome Browser.

Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Tarpey PS, Smith R, Pleasance E, et al. (2009). "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation". Nat. Genet. 41 (5): 535–43. doi:10.1038/ng.367. PMC 2872007. PMID 19377476.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Thiselton DL, McDowall J, Brandau O, et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000147113 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037358 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 "DIPK2B divergent protein kinase domain 2B". Retrieved 2026-07-31.

[pmid11944989-6] Thiselton DL, McDowall J, Brandau O, Ramser J, d'Esposito F, Bhattacharya SS, Ross MT, Hardcastle AJ, Meindl A (April 2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.

[7] "Q9H7Y0 · DIK2B_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-07-31.

[aceview-8] "NCBI AceView: CXorf36". Retrieved 2011-04-28.

[pmid19377476-9] Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, O'Meara S, Latimer C, Dicks E, Menzies A, Stephens P, Blow M, Greenman C, Xue Y, Tyler-Smith C, Thompson D, Gray K, Andrews J, Barthorpe S, Buck G, Cole J, Dunmore R, Jones D, Maddison M, Mironenko T, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Teague J, Butler A, Jenkinson A, Jia M, Richardson D, Shepherd R, Wooster R, Tejada MI, Martinez F, Carvill G, Goliath R, de Brouwer AP, van Bokhoven H, Van Esch H, Chelly J, Raynaud M, Ropers HH, Abidi FE, Srivastava AK, Cox J, Luo Y, Mallya U, Moon J, Parnau J, Mohammed S, Tolmie JL, Shoubridge C, Corbett M, Gardner A, Haan E, Rujirabanjerd S, Shaw M, Vandeleur L, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR (May 2009). "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation". Nat. Genet. 41 (5): 535–43. doi:10.1038/ng.367. PMC 2872007. PMID 19377476.

[NCBI_Protein-10] "NCBI Protein: hypothetical protein LOC79742 isoform 1". Retrieved May 10, 2011.

[GEO_Profiles-11] "NCBI GEO Profiles: CXorf36". Retrieved May 10, 2011.

[KEGG-12] "KEGG: C3orf58". Retrieved May 10, 2011.

[BLAST-13] "NCBI BLAST". Retrieved May 9, 2011.