DIS3

DIS3
Identifiers
Aliases	DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
External IDs	OMIM: 607533; MGI: 1919912; GeneCards: DIS3
Gene location (Human)
Chr.	Chromosome 13 (human)
End	72,782,096 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	99,337,206 bp
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; ventricular zone; ; testicle; ; stromal cell of endometrium; ; ganglionic eminence; ; rectum; ; islet of Langerhans; ; popliteal artery; ; tibial arteries;
	Top expressed in
	primitive streak; ; spermatid; ; epiblast; ; tail of embryo; ; seminiferous tubule; ; somite; ; abdominal wall; ; genital tubercle; ; endothelial cell of lymphatic vessel; ; Paneth cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nuclease activity; hydrolase activity; guanyl-nucleotide exchange factor activity; exonuclease activity; RNA binding; protein binding; endonuclease activity; 3'-5'-exoribonuclease activity; ribonuclease activity;
Cellular component	nucleolus; nucleoplasm; cytoplasm; exosome (RNase complex); nuclear exosome (RNase complex); membrane; nucleus; cytosol; cytoplasmic exosome (RNase complex);
Biological process	exonucleolytic catabolism of deadenylated mRNA; regulation of mRNA stability; CUT catabolic process; rRNA processing; rRNA catabolic process; nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, exonucleolytic; regulation of molecular function; RNA catabolic process; RNA phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	22894
	72662
	ENSG00000083520
	ENSMUSG00000033166
	Q9Y2L1
	Q9CSH3
	NM_001128226; NM_014953; NM_001322348; NM_001322349
	NM_028315; NM_001360050; NM_001360051
	NP_001121698; NP_001309277; NP_001309278; NP_055768
	NP_082591; NP_001346979; NP_001346980
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000083520 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033166 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, et al. (April 2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Human Genetics. 110 (2): 111–121. doi:10.1007/s00439-001-0646-6. PMID 11935316. S2CID 21371347.
↑ Shiomi T, Fukushima K, Suzuki N, Nakashima N, Noguchi E, Nishimoto T (July 1998). "Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3". Journal of Biochemistry. 123 (5): 883–890. doi:10.1093/oxfordjournals.jbchem.a022020. PMID 9562621.
↑ "Entrez Gene: DIS3 DIS3 mitotic control homolog (S. cerevisiae)".
↑ Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, et al. (July 2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". The EMBO Journal. 29 (14): 2342–2357. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–358. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, et al. (February 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Brouwer R, Allmang C, Raijmakers R, van Aarssen Y, Egberts WV, Petfalski E, et al. (March 2001). "Three novel components of the human exosome". The Journal of Biological Chemistry. 276 (9): 6177–6184. doi:10.1074/jbc.M007603200. hdl:2066/186951. PMID 11110791.
Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, et al. (November 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–464. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". Journal of Molecular Biology. 315 (4): 809–818. doi:10.1006/jmbi.2001.5265. hdl:2066/261980. PMID 11812149.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". Journal of Molecular Biology. 323 (4): 653–663. doi:10.1016/S0022-2836(02)00947-6. hdl:2066/186665. PMID 12419256.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, et al. (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–4109. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, et al. (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000083520 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033166 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Rozenblum_2002-5] Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, et al. (April 2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Human Genetics. 110 (2): 111–121. doi:10.1007/s00439-001-0646-6. PMID 11935316. S2CID 21371347.

[Shiomi_1998-6] Shiomi T, Fukushima K, Suzuki N, Nakashima N, Noguchi E, Nishimoto T (July 1998). "Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3". Journal of Biochemistry. 123 (5): 883–890. doi:10.1093/oxfordjournals.jbchem.a022020. PMID 9562621.

[entrez-7] "Entrez Gene: DIS3 DIS3 mitotic control homolog (S. cerevisiae)".

[Tomecki-8] Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, et al. (July 2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". The EMBO Journal. 29 (14): 2342–2357. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386.

DIS3

References

Further reading