DIXDC1

DIXDC1
Identifiers
Aliases	DIXDC1, CCD1, DIX domain containing 1
External IDs	OMIM: 610493; MGI: 2679721; GeneCards: DIXDC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PZ7
Gene location (Human)
Chr.	Chromosome 11 (human)
End	112,022,653 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	50,650,817 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; inferior ganglion of vagus nerve; ; corpus callosum; ; urethra; ; saphenous vein; ; superficial temporal artery; ; subthalamic nucleus; ; ventral tegmental area; ; synovial joint; ; mucosa of paranasal sinus;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; habenula; ; superior colliculus; ; pontine nuclei; ; epithelium of lens; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; neural layer of retina; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; gamma-tubulin binding; protein binding; protein domain specific binding;
Cellular component	cytosol; cell junction; focal adhesion; cytoplasm; cytoskeleton;
Biological process	positive regulation of canonical Wnt signaling pathway; multicellular organism development; positive regulation of Wnt signaling pathway; regulation of microtubule cytoskeleton organization; forebrain ventricular zone progenitor cell division; cerebral cortex radially oriented cell migration; cerebral cortex cell migration; regulation of actin cytoskeleton organization; negative regulation of neuron differentiation; Wnt signaling pathway; cell proliferation in forebrain; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	85458
	330938
	ENSG00000150764
	ENSMUSG00000032064
	Q155Q3
	Q80Y83
	NM_001037954; NM_001278542; NM_033425
	NM_178118; NM_001311069; NM_001374656
	NP_001033043; NP_001265471; NP_219493
	NP_001297998; NP_835219; NP_001361585
	Wikidata
View/Edit Human	View/Edit Mouse

Dixin is a protein that in humans is encoded by the DIXDC1 gene. When active it stops cancer metastasis due to extreme stickiness, both in vitro and in vivo.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000150764 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032064 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Katoh M, Katoh M (July 2003). "KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain". International Journal of Oncology. 23 (1): 145–50. doi:10.3892/ijo.23.1.145. PMID 12792787.
↑ "Entrez Gene: DIXDC1 DIX domain containing 1".
↑ "New gene discovered that stops the spread of deadly cancer".

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (December 2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Ohira M, Morohashi A, Inuzuka H, Shishikura T, Kawamoto T, Kageyama H, Nakamura Y, Isogai E, Takayasu H, Sakiyama S, Suzuki Y, Sugano S, Goto T, Sato S, Nakagawara A (August 2003). "Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets". Oncogene. 22 (35): 5525–36. doi:10.1038/sj.onc.1206853. PMID 12934113.
Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC (September 2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms". The Journal of Biological Chemistry. 279 (38): 39366–73. doi:10.1074/jbc.M404598200. PMID 15262978.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Wang X, Zheng L, Zeng Z, Zhou G, Chien J, Qian C, Vasmatzis G, Shridhar V, Chen L, Liu W (August 2006). "DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein". Biochemical and Biophysical Research Communications. 347 (1): 22–30. doi:10.1016/j.bbrc.2006.06.050. PMID 16814745.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000150764 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032064 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12792787-5] Katoh M, Katoh M (July 2003). "KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain". International Journal of Oncology. 23 (1): 145–50. doi:10.3892/ijo.23.1.145. PMID 12792787.

[entrez-6] "Entrez Gene: DIXDC1 DIX domain containing 1".

[7] "New gene discovered that stops the spread of deadly cancer".

DIXDC1

References

Further reading