DMG-PEG 2000

DMG-PEG 2000
Names
IUPAC name
1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol
Other names
PEG-DMG
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C122H242O50/c1-4-6-8-10-12-14-16-18-20-22-24-26-121(123)171-119-120(172-122(124)27-25-23-21-19-17-15-13-11-9-7-5-2)118-170-117-116-169-115-114-168-113-112-167-111-110-166-109-108-165-107-106-164-105-104-163-103-102-162-101-100-161-99-98-160-97-96-159-95-94-158-93-92-157-91-90-156-89-88-155-87-86-154-85-84-153-83-82-152-81-80-151-79-78-150-77-76-149-75-74-148-73-72-147-71-70-146-69-68-145-67-66-144-65-64-143-63-62-142-61-60-141-59-58-140-57-56-139-55-54-138-53-52-137-51-50-136-49-48-135-47-46-134-45-44-133-43-42-132-41-40-131-39-38-130-37-36-129-35-34-128-33-32-127-31-30-126-29-28-125-3/h120H,4-119H2,1-3H3
    Key: NLDCRRFPGOSAHV-UHFFFAOYSA-N
  • O=C(CCCCCCCCCCCCC)OCC(OC(CCCCCCCCCCCCC)=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
Properties
C122H242O50
Molar mass 2509.20
Appearance powder
Hazards
GHS labelling:
GHS07: Exclamation mark
Danger
H315, H319
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

DMG-PEG 2000 is a synthetic lipid formed by the PEGylation of myristoyl diglyceride. It is used to manufacture lipid nanoparticles that are used in mRNA vaccines, and in particular forms part of the drug delivery system for the Moderna COVID-19 vaccine.

Main applications

DMG-PEG 2000 has similar chemical properties to the phospholipids that make up the cell membrane. This enables lipid nanoparticles composed of it to easily merge with the cell membrane, delivering its contents.

See also

Moderna COVID-19 vaccine nanoparticle ingredients

References

  1. 1 2 3 "DMG-PEG 2000 powder".
  2. 1 2 3 "DMG-PEG(2000)".
  3. ↑ Shirane D, Tanaka H, Nakai Y, Yoshioka H, Akita H (2018). "Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA". Biological & Pharmaceutical Bulletin. 41 (8): 1291–1294. doi:10.1248/bpb.b18-00208. PMID 30068880.
  4. ↑ "Moderna COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 18 Years of Age and Older" (PDF). Centers for Disease Control and Prevention (CDC).