DNA2L

DNA2
Identifiers
Aliases	DNA2, DNA2L, hDNA replication helicase/nuclease 2
External IDs	OMIM: 601810; MGI: 2443732; GeneCards: DNA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EAY
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	68,472,121 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,809,964 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; testicle; ; ventricular zone; ; ganglionic eminence; ; right lobe of liver; ; Epithelium of choroid plexus; ; rectum; ; trabecular bone; ; stromal cell of endometrium;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; primitive streak; ; abdominal wall; ; otic placode; ; epiblast; ; otic vesicle; ; tibiofemoral joint; ; migratory enteric neural crest cell; ; mandibular prominence; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; 4 iron, 4 sulfur cluster binding; nucleotide binding; helicase activity; iron-sulfur cluster binding; metal ion binding; 5'-flap endonuclease activity; DNA helicase activity; ATPase activity; protein binding; catalytic activity; 5'-3' DNA helicase activity; nuclease activity; endonuclease activity; site-specific endodeoxyribonuclease activity, specific for altered base; hydrolase activity; ATP binding; single-stranded DNA helicase activity; RNA binding;
Cellular component	nucleoplasm; gamma DNA polymerase complex; mitochondrial nucleoid; nucleus; mitochondrion; cytoplasm;
Biological process	mitotic telomere maintenance via semi-conservative replication; mitochondrial DNA repair; nucleic acid phosphodiester bond hydrolysis; DNA double-strand break processing; mitochondrial DNA replication; cellular response to DNA damage stimulus; DNA replication checkpoint signaling; positive regulation of DNA replication; metabolism; base-excision repair; DNA replication, removal of RNA primer; DNA replication; telomere maintenance; DNA duplex unwinding; DNA repair; G-quadruplex DNA unwinding; t-circle formation; telomere maintenance via semi-conservative replication; DNA replication, Okazaki fragment processing; replication fork reversal; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1763
	327762
	ENSG00000138346
	ENSMUSG00000036875
	P51530
	Q6ZQJ5
	NM_001080449
	NM_177372
	NP_001073918
	NP_796346
	Wikidata
View/Edit Human	View/Edit Mouse

DNA2-like helicase is an enzyme that in humans is encoded by the DNA2 gene. Dna2, a homolog of DNA2KL present in budding yeast, possesses both helicase and nuclease activity, with which it helps catalyze early steps in homologous recombination.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138346 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036875 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, et al. (March 1997). "Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1". Genomics. 37 (3): 408–410. doi:10.1006/geno.1996.0581. PMID 8938459.
↑ Masuda-Sasa T, Polaczek P, Campbell JL (December 2006). "Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation". The Journal of Biological Chemistry. 281 (50): 38555–38564. doi:10.1074/jbc.M604925200. PMID 17032657.
↑ "Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)".
↑ Mimitou EP, Symington LS (May 2009). "Nucleases and helicases take center stage in homologous recombination". Trends in Biochemical Sciences. 34 (5): 264–272. doi:10.1016/j.tibs.2009.01.010. PMID 19375328.

DNA2L

References

Further reading