DNAI7

DNAI7
Identifiers
Aliases	DNAI7, LAS1, PPP1R54, cancer susceptibility candidate 1, cancer susceptibility 1, cilia and flagella associated protein 94, CASC1, dynein axonemal intermediate chain 7, CFAP94
External IDs	OMIM: 616906; MGI: 2444480; GeneCards: DNAI7
Gene location (Human)
Chr.	Chromosome 12 (human)
End	25,195,162 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	145,156,731 bp
RNA expression pattern
	Top expressed in
	sperm; ; bronchial epithelial cell; ; right uterine tube; ; olfactory zone of nasal mucosa; ; testicle; ; buccal mucosa cell; ; mucosa of paranasal sinus; ; left testis; ; right testis; ; Epithelium of choroid plexus;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; spermatid; ; spermatocyte; ; testicle; ; ovary; ; hypothalamus; ; granulocyte; ; embryo;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	55259
	320662
	ENSG00000118307
	ENSMUSG00000043541
	Q6TDU7
	Q6TDU8
NM_001082972; NM_001082973; NM_001204101; NM_001204102; NM_018272;
	NM_001319977; NM_001319978; NM_001352061; NM_001352062; NM_001352063; NM_001352064; NM_001352065; NM_001352066; NM_001352067; NM_001352068
	NM_177222
NP_001076441; NP_001076442; NP_001191030; NP_001191031; NP_001306906;
	NP_001306907; NP_060742; NP_001338990; NP_001338991; NP_001338992; NP_001338993; NP_001338994; NP_001338995; NP_001338996; NP_001338997
	NP_796196
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein axonemal intermediate chain 7 is a protein that in humans is encoded by the DNAI7 gene, also sometimes known as LAS1; CASC1; CFAP94; or PPP1R54. The protein is sometimes referred to as cancer susceptibility 1.

Casc1, alias Las1, is one of the six genes constituting the mouse Pulmonary adenoma susceptibility 1 (Pas1) locus haplotype.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000118307 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043541 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Cancer susceptibility 1". Retrieved 2018-07-16.
↑ Manenti G, Galbiati F, Giannì-Barrera R, Pettinicchio A, Acevedo A, Dragani TA. Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Oncogene. 2004;23(25):4495–4504.

Manenti G, Galbiati F, Pettinicchio A, Spinola M, Piconese S, Leoni VP, Conti B, Ravagnani F, Incarbone M, Pastorino U, Dragani TA (July 2006). "A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients". Carcinogenesis. 27 (7): 1386–90. doi:10.1093/carcin/bgi332. PMID 16410263.
Kohno T, Kunitoh H, Suzuki K, Yamamoto S, Kuchiba A, Matsuno Y, Yanagitani N, Yokota J (May 2008). "Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias". Carcinogenesis. 29 (5): 957–63. doi:10.1093/carcin/bgn048. PMID 18299280.
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PI, Müller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dörr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJ, Estrada K, Hwang SJ, Bis JC, Rückert IM, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, Völzke H, Campbell H, Meitinger T, Uda M, Witteman JC, Psaty BM, Wichmann HE, Harris TB, Kääb S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BH, Boerwinkle E, O'Donnell CJ (October 2010). "Genome-wide association analysis identifies multiple loci related to resting heart rate". Hum. Mol. Genet. 19 (19): 3885–94. doi:10.1093/hmg/ddq303. PMC 3657480. PMID 20639392.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000118307 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043541 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Cancer susceptibility 1". Retrieved 2018-07-16.

[6] Manenti G, Galbiati F, Giannì-Barrera R, Pettinicchio A, Acevedo A, Dragani TA. Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Oncogene. 2004;23(25):4495–4504.

DNAI7

References

Further reading