DNER

DNER

Identifiers

DNER, UNQ26, bet, delta/notch like EGF repeat containing

External IDs

OMIM: 607299; MGI: 2152889; GeneCards: DNER

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q36.3	Start	229,357,629 bp
Band	2q36.3	End	229,714,555 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1\|1 C5	Start	84,347,560 bp
Band	1\|1 C5	End	84,673,942 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

lateral nuclear group of thalamus

cerebellar vermis

pars reticulata

pars compacta

parotid gland

subthalamic nucleus

external globus pallidus

inferior ganglion of vagus nerve

superior vestibular nucleus

internal globus pallidus

Top expressed in

lobe of cerebellum

cerebellar vermis

ventromedial nucleus

barrel cortex

piriform cortex

habenula

mammillary body

ventral tegmental area

deep cerebellar nuclei

substantia nigra

More reference expression data


More reference expression data

Gene ontology
Molecular function	clathrin binding calcium ion binding protein binding transmembrane signaling receptor activity Notch binding
Cellular component	integral component of membrane soma plasma membrane dendrite early endosome membrane
Biological process	Notch receptor processing synapse assembly central nervous system development neuron migration endocytosis glial cell differentiation skeletal muscle fiber development Notch signaling pathway
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


92737


227325


ENSG00000187957


ENSMUSG00000036766


Q8NFT8


Q8JZM4

RefSeq (mRNA)


NM_139072


NM_152915

RefSeq (protein)


NP_620711


NP_690879

Location (UCSC)

Chr 2: 229.36 – 229.71 Mb

Chr 1: 84.35 – 84.67 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Delta and Notch-like epidermal growth factor-related receptor is a protein that in humans is encoded by the DNER gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187957 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036766 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M (July 2002). "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons". The Journal of Biological Chemistry. 277 (28): 25400–25407. doi:10.1074/jbc.M110793200. PMID 11950833.
↑ Nishizumi H, Komiyama T, Miyabayashi T, Sakano S, Sakano H (May 2002). "BET, a novel neuronal transmembrane protein with multiple EGF-like motifs". Neuroreport. 13 (6): 909–915. doi:10.1097/00001756-200205070-00035. PMID 11997712. S2CID 8325151.
↑ "Entrez Gene: DNER delta/notch-like EGF repeat containing".

Further reading

Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA (June 2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". Journal of Proteome Research. 5 (6): 1493–1503. doi:10.1021/pr050492k. PMID 16740002.

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