DOC2A

DOC2A
Identifiers
Aliases	DOC2A, Doc2, double C2 domain alpha
External IDs	OMIM: 604567; MGI: 109446; GeneCards: DOC2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MJJ
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,023,270 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,451,877 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; Brodmann area 9; ; left testis; ; right testis; ; anterior cingulate cortex; ; prefrontal cortex; ; right uterine tube; ; amygdala; ; mucosa of transverse colon;
	Top expressed in
	ventromedial nucleus; ; cingulate gyrus; ; primary motor cortex; ; motor neuron; ; lumbar subsegment of spinal cord; ; anterior amygdaloid area; ; piriform cortex; ; barrel cortex; ; prefrontal cortex; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium-dependent phospholipid binding; clathrin binding; calcium ion binding; syntaxin binding; protein binding;
Cellular component	neuron projection; lysosome; synapse; synaptic vesicle membrane; membrane; cytoplasmic vesicle; plasma membrane; nucleus; nucleolus; cell junction; exocytic vesicle; extrinsic component of synaptic vesicle membrane;
Biological process	nervous system development; regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; exocytosis; chemical synaptic transmission; calcium ion-regulated exocytosis of neurotransmitter; vesicle fusion; spontaneous neurotransmitter secretion;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8448
	13446
	ENSG00000149927
	ENSMUSG00000052301
	Q14183
	Q7TNF0
	NM_001282062; NM_001282063; NM_001282068; NM_003586
	NM_010069; NM_001368355; NM_001368356; NM_001368357; NM_001368358
	NP_001268991; NP_001268992; NP_001268997; NP_003577
	NP_034199; NP_001355284; NP_001355285; NP_001355286; NP_001355287
	Wikidata
View/Edit Human	View/Edit Mouse

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca²⁺-dependent neurotransmitter release.

Interactions

DOC2A has been shown to interact with UNC13B and UNC13A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149927 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052301 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.
1 2 Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. Bibcode:1998PNAS...9511418M. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.
1 2 "Entrez Gene: DOC2A double C2-like domains, alpha".
↑ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.
↑ "Protein unc-13 homolog A". UniProt.

Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557.
Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738. S2CID 17948539.
Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149927 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052301 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7826360-5] Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.

[pmid9736751-6] 1 2 Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. Bibcode:1998PNAS...9511418M. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.

[entrez-7] 1 2 "Entrez Gene: DOC2A double C2-like domains, alpha".

[pmid9195900-8] Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.

[9] "Protein unc-13 homolog A". UniProt.

DOC2A

Interactions

References

Further reading