DPYSL5

DPYSL5
Identifiers
Aliases	DPYSL5, CRAM, CRMP-5, CRMP5, Ulip6, dihydropyrimidinase like 5, CV2, RTSC4
External IDs	OMIM: 608383; MGI: 1929772; GeneCards: DPYSL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B90, 4B91, 4B92
Gene location (Human)
Chr.	Chromosome 2 (human)
End	26,950,351 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	30,956,719 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; C1 segment; ; nucleus accumbens; ; putamen; ; substantia nigra; ; caudate nucleus; ; corpus callosum; ; hypothalamus; ; inferior ganglion of vagus nerve;
	Top expressed in
	tail of embryo; ; ganglionic eminence; ; ventricular zone; ; lumbar spinal ganglion; ; neural layer of retina; ; Rostral migratory stream; ; superior cervical ganglion; ; genital tubercle; ; epiblast; ; seminiferous tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; protein binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; dihydropyrimidinase activity;
Cellular component	cytoplasm; cytosol; soma; dendrite;
Biological process	signal transduction; nervous system development; axon guidance; pyrimidine nucleobase catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56896
	65254
	ENSG00000157851
	ENSMUSG00000029168
	Q9BPU6
	Q9EQF6
	NM_020134; NM_001253723; NM_001253724
	NM_023047; NM_001356948; NM_001356949
	NP_001240652; NP_001240653; NP_064519
	NP_075534; NP_001343877; NP_001343878
	Wikidata
View/Edit Human	View/Edit Mouse

Dihydropyrimidinase-related protein 5 is an enzyme that in humans is encoded by the DPYSL5 gene.

Members of the CRMP family, such as DPYSL5, are believed to play a role in growth cone guidance during neural development.[supplied by OMIM]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000157851 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029168 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S (Oct 2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J Biol Chem. 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.
↑ Horiuchi M, El Far O, Betz H (Nov 2000). "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain". FEBS Lett. 480 (2–3): 283–6. doi:10.1016/S0014-5793(00)01952-9. PMID 11034345. S2CID 42248702.
1 2 "Entrez Gene: DPYSL5 dihydropyrimidinase-like 5".

External links

Overview of all the structural information available in the PDB for UniProt: Q9BPU6 (Dihydropyrimidinase-related protein 5) at the PDBe-KB.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000157851 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029168 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10851247-5] Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S (Oct 2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J Biol Chem. 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.

[pmid11034345-6] Horiuchi M, El Far O, Betz H (Nov 2000). "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain". FEBS Lett. 480 (2–3): 283–6. doi:10.1016/S0014-5793(00)01952-9. PMID 11034345. S2CID 42248702.

[entrez-7] 1 2 "Entrez Gene: DPYSL5 dihydropyrimidinase-like 5".

DPYSL5

References

Further reading

External links