David Baulcombe

Sir
David Baulcombe
FRS FMedSci MAE
Born
David Charles Baulcombe

(1952-04-07) 7 April 1952 (age 74)
Solihull, England
Education
Known for
SpouseRose Eden (m. 1976)
Children1 son, 3 daughters
Awards
Scientific career
Fields
Workplaces
ThesisThe Processing and Intracellular Transport of Messenger RNA in a Higher Plant (1976)
John Ingle
Doctoral students
Website

Sir David Charles Baulcombe FMedSci FRS (born 7 April 1952) is a British plant scientist and geneticist. He was Regius Professor of Botany at the University of Cambridge (Emeritus since 2019) and is currently Biological Secretary and Vice President of the Royal Society. In 2026, Baulcombe was announced as the next Master of Trinity College, Cambridge.

Early life and education

David Baulcombe was born on 7 April 1952 in the United Kingdom, in Solihull, Warwickshire, (in England's Midlands), into what he describes as "a non-scientific family".

As a child growing up in England's West Midlands, David Baulcombe developed a fascination for algae, mosses, and other 'lower plants', which eventually led him to study botany at Leeds before shifting his focus to molecular biology.

He received his Bachelor of Science degree in botany from the University of Leeds in 1973, and continued his studies at the University of Edinburgh, receiving his Doctor of Philosophy degree in 1977 for research on Messenger RNA in vascular plants, supervised by John Ingle.

Career

After his doctoral research, Baulcombe spent the next four years as a postdoctoral fellow at McGill University from January 1977 to November 1978, and then at the University of Georgia until December 1980. He then moved to the Plant Breeding Institute in Cambridge (PBI) from 1980 until 1988 before joining the Sainsbury Laboratory in Norwich in 1988. In March 2007 he became the professor of botany at the University of Cambridge and in 2009 was elected as a Fellow of Trinity College, Cambridge. In 2009, the Cambridge professorship was renamed "Regius Professor of Botany": the first Regius Professorship created by Queen Elizabeth II.

Since 2024, David Baulcombe has been Biological Secretary and Vice President of the Royal Society. In 2026, Baulcombe was announced as the next Master of Trinity College, succeeding Sally Davies.

Research

One of Baulcombe's major discoveries in 1999 with Andrew Hamilton was of small interfering RNA (siRNA) that is the specificity determinant in RNA-mediated gene silencing in plants. These small RNAs were subsequently discovered in animals and fungi as part of a process first described as RNA interference by Fire and Mello in 1996. Fire and Mello were awarded the Nobel Prize in Physiology or Medicine in 2006 for their work, although some have argued that Baulcombe was among those overlooked for that year's prize.

Following the discover of small interfering RNAs, the Baulcombe research group at the Sainsbury Laboratory helped unravel the importance of RNA silencing and small interfering RNA in epigenetics and in defence against viruses. More recently, siRNAs have been developed as drugs to treat diseases in humans.

Other interests of the Baulcombe group involve disease resistance mechanisms in plants through the actions of NB-LRR (NLR) proteins. These proteins act in pairs with one partner serving as a sensor and the other as a helper. Baulcombe and his then PHD student Jack Peart provided the first evidence for NLR proteins acting as a pair.

Personal life

Baulcombe has been married to Rose Eden since 1976, and they have four children. His interests include music, sailing, and hill walking.

Honours and awards

In June 2009, Baulcombe was knighted by Queen Elizabeth II in the 2009 Birthday Honours List, "for services to plant science".

Baulcombe has also received the following honours and awards:

References

  1. 1 2 3 4 PAS Staff & Baulcombe, David (7 October 2024). "Ordinary Academicians: Prof. David Baulcombe". Vatican City: The Pontifical Academy of Sciences (PAS). Retrieved 7 October 2024.
  2. 1 2 3 4 5 Staff of Who's Who & Baulcombe, David Charles (2014). "Baulcombe, Prof. Sir David (Charles)". Who's Who (online ed.). Oxford, England: OUP. doi:10.1093/ww/9780199540884.013.U12688. (Subscription or UK public library membership required.)
  3. 1 2 Bailcombe, David (7 October 2024). "David Baulcombe—Curriculum Vitae" (PDF). PlantSci.Cam.Ac.UK. University of Cambridge. Retrieved 7 October 2024.[self-published source?]
  4. 1 2 3 4 5 6 Staff of the Royal Society & Baulcombe, David (7 October 2024). "Fellows Directory: Professor Sir David Baulcombe FMedSci FRS". RoyalSociety.org. London: The Royal Society. Retrieved 7 October 2024.
  5. ↑ Voinnet, Olivier (2001). Molecular analysis of post-transcriptional gene silencing : mechanisms and roles. copac.jisc.ac.uk (PhD thesis). University of East Anglia. OCLC 556857695. EThOS uk.bl.ethos.390649.[permanent dead link]
  6. ↑ Martienssen, Robert A. (1986). The molecular genetics of alpha-amylase gene families in wheat (Triticum aestivum L.). copac.jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 499910070. EThOS uk.bl.ethos.382600.[permanent dead link]
  7. 1 2 "Professor Sir David Baulcombe FMedSci FRS | Royal Society Fellow". royalsociety.org. Retrieved 10 June 2026.
  8. 1 2 fionaholland (15 June 2026). "Trinity College's next Master: Sir David Baulcombe". Trinity College Cambridge. Retrieved 15 June 2026.
  9. 1 2 APS Staff & Baulcombe, David Charles (2003). "Ruth Allen Award [2002 awardee biography]" (PDF). Phytopathology. 93 (1). St. Paul, MN: American Phytopathological Society (APS): 23. Archived from the original (PDF) on 29 September 2007. Retrieved 7 October 2024. David Charles Baulcombe was born in Solihull, Warwickshire, United Kingdom in 1952. He received his B.S. degree in botany from the University of Leeds and his Ph.D. from the University of Edinburgh. Since 1988, Dr. Baulcombe has been at the Sainsbury Laboratory Norwich, U.K. ... Dr. Baulcombe also has demonstrated that while viruses can induce gene silencing some viruses encode proteins that suppress gene silencing. Dr. Baulcombe is internationally renowned for his research and serves on several committees and study sections. In 2001, Dr. Baulcombe was elected a fellow of the Royal Society.
  10. 1 2 3 4 Staff of Curr. Biol. & Baulcombe, David (6 February 2007). "Q & A: David Baulcombe" (interview). Current Biology. 17 (3): R73–R74. Bibcode:2007CBio...17R..73B. doi:10.1016/j.cub.2007.01.022. PMID 17328111. S2CID 20568141. David Baulcombe was born in the Midlands of the UK into a non-scientific family. He studied botany as an undergraduate at Leeds University (BSc 1973) and started his own research group at the Plant Breeding Institute in Cambridge after his PhD in Edinburgh (1977) and spells as a postdoc in Montreal and Athens Georgia. He has been in the Sainsbury Laboratory in Norwich since 1988 where he is a senior research scientist. His research interests have spanned plant hormones, root nodule symbioses, disease resistance, virology and over the last ten years have focused on RNA silencing and epigenetics. David has served as President of the International Society of Plant Molecular Biology and his research has been recognised by various awards, including elections to the Royal Society and the US National Academy of Sciences (foreign associate). His current interests include a systems approach to understanding the role of short silencing RNA in regulatory networks.
  11. ↑ Baulcombe, David (6 February 2007). "David Baulcombe". Current Biology. 17 (3): R73–R74. Bibcode:2007CBio...17R..73B. doi:10.1016/j.cub.2007.01.022. ISSN 0960-9822. PMID 17328111.
  12. ↑ "David Baulcombe | Gruber Foundation". gruber.yale.edu. Retrieved 28 August 2025.
  13. ↑ Baulcombe, David (1976). The Processing and Intracellular Transport of Messenger RNA in a Higher Plant (PhD thesis). University of Edinburgh. hdl:1842/14914. EThOS uk.bl.ethos.641386. Open access icon
  14. ↑ "David Baulcome Thesis". University of Edinburgh, Research Archive. 1976. Retrieved 22 September 2025. {{cite journal}}: Cite journal requires |journal= (help)
  15. 1 2 "Baulcombe, Prof. Sir David (Charles), (born 7 April 1952), Regius Professor of Botany, since 2009, and Royal Society Research Professor, since 2007, Department of Plant Sciences, University of Cambridge (Professor of Botany, 2007–09); Fellow of Trinity College, Cambridge, since 2009", Who's Who, Oxford University Press, 1 December 2007, doi:10.1093/ww/9780199540884.013.U12688, ISBN 978-0-19-954088-4, retrieved 10 June 2026
  16. ↑ "Our history and mission". The Sainsbury Laboratory. Retrieved 10 June 2026.
  17. ↑ "Master & Fellows". Trinity College Cambridge. Retrieved 10 June 2026.
  18. ↑ "A new Regius Professor for the University". 24 November 2009. Archived from the original on 27 November 2009.
  19. ↑ "A new Regius Professor for the University". University of Cambridge. 23 November 2009. Retrieved 10 June 2026.
  20. ↑ Hamilton, Andrew J.; Baulcombe, David C. (29 October 1999). "A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants". Science. 286 (5441): 950–952. doi:10.1126/science.286.5441.950. PMID 10542148.
  21. 1 2 Zamore, Phillip D. (15 December 2006). "RNA Interference: Big Applause for Silencing in Stockholm". Cell. 127 (6): 1083–1086. doi:10.1016/j.cell.2006.12.001. ISSN 0092-8674. PMID 17174883.
  22. ↑ Daneholt, Bertil (2006). "The Nobel Prize in Physiology or Medicine 2006: Advanced Information - RNA interference". NobelPrize.org. Stockholm, Sweden: The Nobel Foundation. [Section "The discovery of RNA interference"]. Archived from the original on 23 October 2006. Retrieved 25 January 2007. Andrew Fire and Craig Mello published their break-through study on the mechanism of RNA interference in Nature in 1998...
  23. ↑ Westly, Erica (6 October 2008). "No Nobel for You: Top 10 Nobel Snubs". ScientificAmerican.com. London and Berlin: Springer Nature. [Slide 7.) Victor Ambros, Gary Ruvkun and David Baulcombe--missed out on the 2006 Nobel Prize in Physiology]. Archived from the original on 20 March 2011. Retrieved 11 September 2012. ...many felt the scientists who did the research that helped lead to Fire and Mello's discovery--Ambros... and Ruvkun... working with worms and Baulcombe..., plants...--deserved a place in Nobel history as well... Nobel committees rarely revisit research areas for which they've already handed out prizes. In 2008, though, Ambros, Ruvkun and Baulcombe started racking up prestigious honors, such as the Franklin Medal and the Lasker Award, suggesting they might still have a shot at sharing their own Nobel some day.
  24. ↑ Ding, Shou-Wei; Voinnet, Olivier (10 August 2007). "Antiviral Immunity Directed by Small RNAs". Cell. 130 (3): 413–426. doi:10.1016/j.cell.2007.07.039. ISSN 0092-8674. PMC 2703654. PMID 17693253.
  25. ↑ "From small discoveries to transformational drug design". 16 December 2025. Retrieved 10 June 2026.
  26. ↑ Cui, Haitao; Tsuda, Kenichi; Parker, Jane E. (29 April 2015). "Effector-Triggered Immunity: From Pathogen Perception to Robust Defense". Annual Review of Plant Biology. 66 (1): 487–511. Bibcode:2015AnRPB..66..487C. doi:10.1146/annurev-arplant-050213-040012. ISSN 1543-5008. PMID 25494461.
  27. ↑ Peart, Jack R.; Mestre, Pere; Lu, Rui; Malcuit, Isabelle; Baulcombe, David C. (24 May 2005). "NRG1, a CC-NB-LRR Protein, together with N, a TIR-NB-LRR Protein, Mediates Resistance against Tobacco Mosaic Virus". Current Biology. 15 (10): 968–973. Bibcode:2005CBio...15..968P. doi:10.1016/j.cub.2005.04.053. ISSN 0960-9822. PMID 15916955.
  28. ↑ "Baulcombe, Sir David (Charles), (born 7 April 1952), Regius Professor of Botany, University of Cambridge, 2009–19, now Emeritus (Professor of Botany, 2007–09; Edward Penley Abraham Royal Society Research Professor, 2007–22); Fellow of Trinity College, Cambridge, 2009–19, now Emeritus". Who's Who & Who Was Who. doi:10.1093/ww/9780199540884.013.U12688. Archived from the original on 20 April 2025.
  29. ↑ From the Central Chancery of the Orders of Knighthoods, St. James’s Palace, London, recorded in The Gazette (London Gazette), issue 59090, 13 June 2009, see Supplement 1, p. 1.
  30. ↑ EMBO Staff & Baulcombe, David (2017) [1997]. "Details: EMBO Member David Baulcombe". People.EMBO.org. Archived from the original on 6 August 2017. University of Cambridge—United Kingdom—EMBO 1997—Disease resistance, RNA and epigenetics in plants—Much of my current research follows from the discovery in my Norwich laboratory of a novel type of regulatory RNA – siRNA. Current projects in the laboratory focus on the mechanisms of siRNA-mediated regulation and their influence on natural variation. Outside the laboratory I promote the use of plant biotechnology for crop improvement. I am particularly interested in technologies addressing problems in developing countries.
  31. 1 2 3 4 "News and Events - Current News". PlantSci.Cam.Ac.UK. University of Cambridge, Department of Plant Sciences. 28 March 2007. Archived from the original on 1 July 2007. Retrieved 7 October 2024. The Department is pleased to announce the election of Professor David Baulcombe FRS, as the new Professor of Botany with effect from 1 September 2007. Professor Baulcombe, is currently a Senior Research Scientist at the Sainsbury Laboratory, John Innes Centre in Norwich. Trained as a botanist, his research interests are in the area of plant gene expression generally. As a result of his studies of expressing viral genes in plants, he established the role of small RNAs in RNA silencing, a mechanism for regulation of gene expression that is universal (see an interview). Professor Baulcombe has been the recipient of numerous prizes and awards in recognition of his work, including the Massry Prize from the Massry Foundation, University of Southern California in 2005 and the Wiley Prize in Biomedical Science from the Wiley Foundation, Rockefeller University, both shared with Craig Mello and Andrew Fire. He was elected to the Royal Society in 2001, and as a foreign associate member of the National Academy of Sciences (USA) in 2005.
  32. ↑ AE Staff & Baulcombe, David (2024) [2002]. "Members of the Academy of Europe: David Baulcombe". AE-Info.org. London and München: Academia Europaea (AE). Retrieved 7 October 2024. David Baulcombe / Membership Number: 2159 / Membership type: Ordinary / Section: Cell & Developmental Biology / Elected: 2002.
  33. ↑ Wiley Foundation Staff (2003). "The Wiley Prize in Biomedical Sciences: Our Award Recipients—2003". Wiley.com. Hoboken, NJ: Wiley Foundation, John Wiley & Sons. Retrieved 7 October 2024. The 2nd annual Wiley Prize in the Biomedical Sciences was awarded to Andrew Z. Fire, Craig C. Mello, Thomas Tuschl, and David Baulcombe for their respective contributions to discoveries of novel mechanisms for regulating gene expression by small interfering RNAs (siRNA).
  34. ↑ Staff of The Franklin Institute (2024) [April 2006]. "The Franklin Institute Awards: David Baulcombe [Benjamin Franklin Medal]". FI.edu. Philadelphia, PA: The Franklin Institute. Retrieved 8 October 2024. DavidBaulcombe / Year—2008 / Subject—Life Science / Award—Benjamin Franklin Medal / Affiliation—University of Cambridge... / Citation—With Gary Ruvkun and Victor Ambros, for their discovery of small RNAs that turn off genes. Their pioneering work initiated a paradigm shift in our perception of the ways genes are regulated, and this insight is making possible major new genetic tools for basic research, and for improving agriculture and human health.. See also this archive of an earlier web post, archive date 15 May 2008.
  35. ↑ Green, Pamela (April 2011). "2008 Benjamin Franklin Medal in Life Science is Presented to...". Journal of the Franklin Institute. 348 (3). Amsterdam, The Netherlands: Elsevier: 500ff. doi:10.1016/j.jfranklin.2010.05.004. Retrieved 8 October 2024. 2008 Benjamin Franklin medal in life science is Presented to Victor Ambros, Ph.D. (University of Massachusetts Medical School, Worcester, Massachusetts), Gary Ruvkun, Ph.D. (Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts) and David Baulcombe, Ph.D., FRS (University of Cambridge, Cambridge, UK).
  36. ↑ "Tiny RNAs that Regulate Gene Function". Lasker Foundation. Retrieved 22 September 2025.
  37. ↑ Staff of the Royal Society (7 October 2024). "Awards: Humphry Davy and Claude Bernard Lectures". RoyalSociety.org. London: The Royal Society. Archived from the original on 30 June 2011. Retrieved 7 October 2024.
  38. ↑ "Professor Sir David Baulcombe FRS FMedSci". Academy of Medical Sciences. Retrieved 9 June 2026.
  39. ↑ "David Baulcombe International Balzan Prize Foundation". balzan.org. Archived from the original on 22 May 2015. Retrieved 22 May 2015.
  40. ↑ "Epigenetics researcher a 2012 Balzan prizewinner | Laboratory Product News". Archived from the original on 15 September 2012. Retrieved 11 September 2012.
  41. ↑ "2014 Gruber Genetics Prize Press Release | The Gruber Foundation". gruber.yale.edu. Retrieved 1 February 2018.
  42. ↑ MGC Staff (2024) [2014]. "McClintock Prize Past Winners—2014: David C. Baulcombe (University of Cambridge)". MaizeGDB.org. Madison, Wisconsin: Maize Genetics Cooperation (MGC). Retrieved 7 October 2024. The Maize Genetics Executive Committee would like to announce that the winner of the inaugural McClintock Prize for Plant Genetics and Genome Studies is Prof. Sir David Baulcombe of the University of Cambridge. This award is in recognition of his exceptional contributions in the field of plant epigenetics, a field in which Dr. McClintock was one of the pioneers.
  43. ↑ "David Baulcombe". Royal Society Edinburgh. Retrieved 22 September 2025.
  44. ↑ "List of all Honorary Graduates and Chancellor's Medallists". warwick.ac.uk. Retrieved 3 May 2024.

Further reading