Dextran 70
| Clinical data | |
|---|---|
| Trade names | RescueFlow, others |
| AHFS/Drugs.com | Monograph |
| Routes of administration | intravenous |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
| DrugBank | |
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| Chemical and physical data | |
| Molar mass | 70000 Da |
Dextran 70 is a polymer of glucose produced by bacteria. It is used by injection into a vein to expand blood volume. Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available. However, it does not carry oxygen. It also slows the clotting of blood when injected. It is also used as an eye lubricant and as a carrier for intravenous technetium.
Common side effects include vomiting, fever, and joint pains. Other side effects include allergic reactions and poor blood clotting. It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder. It is not recommended during pregnancy. It works by pulling fluid from the extravascular space into the blood vessels.
Dextran 70 was approved for medical use in 1947. It is on the World Health Organization's List of Essential Medicines. It comes in either sodium chloride solution or glucose solution.
Chemical identity
Dextrans are glucose polymers with alpha 1-6 linkage produced by bacteria. Dextran 70 refers to the specific version having an average molecular mass of 70,000.
Adverse effects
When injected by excessive amounts, dextran damages the kidney by making the blood too viscous. Dextran accumulates in and is metabolized by hepatocytes; a dose too high can lead to oxidative stress in these cells manifesting as liver damage. Keeping a log of the amount given and monitoring kidney and liver function is recommended. Some people are allergic to dextran.
References
- 1 2 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 248, 257–58, 279, 287. hdl:10665/44053. ISBN 978-92-4-154765-9.
- 1 2 3 4 5 6 "Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016.
- 1 2 3 4 Miao KH, Guthmiller KB (July 15, 2026). "Dextran". StatPearls. StatPearls Publishing. PMID 32491563. Retrieved July 15, 2026 – via PubMed.
- ↑ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 978-0-85711-156-2.
- ↑ BeMiller JN, Whistler RL (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 978-0-08-092654-4. Archived from the original on 2017-01-03.
- ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
External links
- "Dextran 70". Drug Information Portal. U.S. National Library of Medicine. 2022-08-16. Archived from the original on November 27, 2020.
