EAF2

EAF2
Identifiers
Aliases	EAF2, BM040, TRAITS, U19, ELL associated factor 2
External IDs	OMIM: 607659; MGI: 2146616; GeneCards: EAF2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	121,886,526 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,695,365 bp
RNA expression pattern
	Top expressed in
	bone marrow cell; ; monocyte; ; lymph node; ; trabecular bone; ; granulocyte; ; appendix; ; kidney tubule; ; epithelium of nasopharynx; ; rectum; ; spleen;
	Top expressed in
	female urethra; ; right kidney; ; proximal tubule; ; lacrimal gland; ; epithelium of urethra; ; epithelium of female urethra; ; seminal vesicula; ; pelvic part of vagina; ; male urethra; ; epithelium of male urethra;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein binding;
Cellular component	nuclear speck; transcription elongation factor complex; super elongation complex; nucleus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of cell growth; negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; apoptotic process; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55840
	106389
	ENSG00000145088
	ENSMUSG00000022838
	Q96CJ1
	Q91ZD6
	NM_018456; NM_001320041
	NM_001113401; NM_001113405; NM_134111; NM_001358102
	NP_001306970; NP_060926
	NP_001106872; NP_001106876; NP_598872; NP_001345031
	Wikidata
View/Edit Human	View/Edit Mouse

ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene. It is part of the EAF family of proteins and plays a role in transcriptional elongation by interacting with ELL proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145088 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022838 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ (February 2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–2362. doi:10.1182/blood-2002-06-1664. PMID 12446457.
↑ Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (August 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Research. 63 (15): 4698–4704. PMID 12907652.
↑ "Entrez Gene: EAF2 ELL associated factor 2".

Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". Journal of Biochemistry. 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297.
Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proceedings of the National Academy of Sciences of the United States of America. 102 (29): 10094–10098. Bibcode:2005PNAS..10210094K. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
Xiao W, Jiang F, Wang Z (2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". The Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057. S2CID 32749490.
Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Letters. 253 (2): 265–272. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145088 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Simone_2003-5] 1 2 Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ (February 2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–2362. doi:10.1182/blood-2002-06-1664. PMID 12446457.

[Xiao_2003-6] Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (August 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Research. 63 (15): 4698–4704. PMID 12907652.

[entrez-7] "Entrez Gene: EAF2 ELL associated factor 2".

EAF2

References

Further reading