EBI3

EBI3
Identifiers
Aliases	EBI3, IL-27B, IL27B, Epstein-Barr virus induced 3, IL35B
External IDs	OMIM: 605816; MGI: 1354171; GeneCards: EBI3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	7U7N, 7Z0L, 7ZG0, 7ZXK, 8D85
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,237,528 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,264,022 bp
RNA expression pattern
	Top expressed in
	placenta; ; decidua; ; spleen; ; appendix; ; lymph node; ; gonad; ; gallbladder; ; right adrenal gland; ; C1 segment; ; right coronary artery;
	Top expressed in
	granulocyte; ; splanchnocranium; ; rib; ; hyoid bone; ; humerus; ; stroma of bone marrow; ; sphenoid bone; ; Meckel's cartilage; ; lesser wing of sphenoid bone; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; cytokine activity; interleukin-27 receptor binding; protein binding; ciliary neurotrophic factor receptor activity; cytokine binding;
Cellular component	extracellular region; plasma membrane; membrane; extracellular space; endoplasmic reticulum lumen; external side of plasma membrane; receptor complex; ciliary neurotrophic factor receptor complex; CNTFR-CLCF1 complex;
Biological process	T-helper 1 type immune response; T cell proliferation; humoral immune response; positive regulation of alpha-beta T cell proliferation; regulation of signaling receptor activity; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; ciliary neurotrophic factor-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10148
	50498
	ENSG00000105246
	ENSMUSG00000003206
	Q14213
	O35228
	NM_005755
	NM_015766
	NP_005746
	NP_056581
	Wikidata
View/Edit Human	View/Edit Mouse

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.

Function

This gene was identified by the induction of its expression in B lymphocytes by Epstein–Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells. IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105246 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003206 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3".
↑ Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC 189923. PMID 8551575.
1 2 Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature. 450 (7169): 566–9. Bibcode:2007Natur.450..566C. doi:10.1038/nature06306. PMID 18033300. S2CID 4425281.
↑ Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:10.1038/ni1375. PMID 16906167. S2CID 32503719.
↑ Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi:10.1002/eji.200737810. PMID 17874423.

External links

EBI3 human gene location in the UCSC Genome Browser.
EBI3 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105246 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003206 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3".

[pmid8551575-6] Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC 189923. PMID 8551575.

[pmid18033300-7] 1 2 Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature. 450 (7169): 566–9. Bibcode:2007Natur.450..566C. doi:10.1038/nature06306. PMID 18033300. S2CID 4425281.

[pmid16906167-8] Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:10.1038/ni1375. PMID 16906167. S2CID 32503719.

[pmid17874423-9] Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi:10.1002/eji.200737810. PMID 17874423.

EBI3

Function

References

Further reading

External links