ECT2L

ECT2L
Identifiers
Aliases	ECT2L, ARHGEF32, C6orf91, FBXO49, LFDH, dJ509I19.2, dJ509I19.3, dJ509I19.5, epithelial cell transforming 2 like
External IDs	MGI: 3641723; GeneCards: ECT2L
Gene location (Human)
Chr.	Chromosome 6 (human)
End	138,904,070 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	18,086,638 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; olfactory zone of nasal mucosa; ; left ventricle; ; right lung; ; Achilles tendon; ; pituitary gland; ; gonad; ; right auricle of heart; ; anterior pituitary; ; endometrium;
	Top expressed in
	embryo; ; hypothalamus; ; embryo; ; ovary; ; proximal tubule; ; lung; ; right kidney; ; olfactory bulb; ; thymus; ; muscle tissue;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	345930
	100045792
	ENSG00000203734
	ENSMUSG00000071392
	Q008S8
	n/a
	NM_001077706; NM_001195037
	NM_001195036; NM_001370991
	NP_001071174; NP_001181966
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Epithelial cell transforming sequence 2 oncogene-like is a protein that in humans is encoded by the ECT2L gene.

Clinical relevance

Recurrent mutations of this gene have been associated to cases of acute lymphoblastic leukaemia.

1 2 3 GRCh38: Ensembl release 89: ENSG00000203734 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071392 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Epithelial cell transforming sequence 2 oncogene-like". Retrieved 2012-02-19.
↑ Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG (2012). "The genetic basis of early T-cell precursor acute lymphoblastic leukaemia". Nature. 481 (7380): 157–163. Bibcode:2012Natur.481..157Z. doi:10.1038/nature10725. PMC 3267575. PMID 22237106.

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