EDEM1
Protein-coding gene in the species Homo sapiens
ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene .
Further reading
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain" . DNA Res . 3 (5): 321– 9, 341– 54. doi :10.1093/dnares/3.5.321 . PMID 9039502 .
Hosokawa N, Wada I, Hasegawa K, et al. (2001). "A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation" . EMBO Rep . 2 (5): 415– 22. doi :10.1093/embo-reports/kve084 . PMC 1083879 . PMID 11375934 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Oda Y, Hosokawa N, Wada I, Nagata K (2003). "EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin". Science . 299 (5611): 1394– 7. doi :10.1126/science.1079181 . PMID 12610305 . S2CID 28716209 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Olivari S, Galli C, Alanen H, et al. (2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation" . J. Biol. Chem . 280 (4): 2424– 8. doi :10.1074/jbc.C400534200 . PMID 15579471 .
Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation" . J. Cell Biol . 172 (3): 383– 93. doi :10.1083/jcb.200507057 . PMC 2063648 . PMID 16449189 .
Hosokawa N, Wada I, Natsuka Y, Nagata K (2006). "EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin" . Genes Cells . 11 (5): 465– 76. doi :10.1111/j.1365-2443.2006.00957.x . PMID 16629899 . S2CID 19832510 .
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 .
Zuber C, Cormier JH, Guhl B, et al. (2007). "EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites" . Proc. Natl. Acad. Sci. U.S.A . 104 (11): 4407– 12. Bibcode :2007PNAS..104.4407Z . doi :10.1073/pnas.0700154104 . PMC 1810509 . PMID 17360537 .