EIF5AL1

EIF5AL1
Identifiers
Aliases	EIF5AL1, EIF5AP1, bA342M3.3, eukaryotic translation initiation factor 5A-like 1, EIF5A, eIF-5A, eIF-5A1, eIF-4D, eIF-5A-1, eukaryotic translation initiation factor 5A like 1
External IDs	GeneCards: EIF5AL1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	79,516,440 bp
RNA expression pattern
	Top expressed in
	testicle; ; left testis; ; right testis; ; thymus; ; mucosa of transverse colon; ; stromal cell of endometrium; ; bone marrow cell; ; muscle of thigh; ; liver; ; gastrocnemius muscle;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	translation elongation factor activity; RNA binding; ribosome binding;
Cellular component	nuclear pore; endoplasmic reticulum membrane; nucleus; membrane; cytoplasm; endoplasmic reticulum;
Biological process	protein transport; translational frameshifting; positive regulation of translational elongation; translational elongation; mRNA transport; protein biosynthesis; positive regulation of translational termination;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	143244
	n/a
	ENSG00000253626
	n/a
	Q6IS14
	n/a
	NM_001099692
	n/a
	NP_001093162
	n/a
	Wikidata
View/Edit Human

Eukaryotic translation initiation factor 5A-1-like is a protein that in humans is encoded by the gene EIF5AL1 (previously EIF5AP1). The EIF5AL1 protein is predicted to be involved in translational elongation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000253626 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "EIF5AL1 - eukaryotic translation initiation factor 5A like 1".

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Clement PM, Johansson HE, Wolff EC, Park MH (2006). "Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells". FEBS J. 273 (6): 1102–1114. doi:10.1111/j.1742-4658.2006.05135.x. PMC 4406228. PMID 16519677.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Facchiano AM, Stiuso P, Chiusano ML, et al. (2002). "Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A)". Protein Eng. 14 (11): 881–890. doi:10.1093/protein/14.11.881. PMID 11742107.
Lipowsky G, Bischoff FR, Schwarzmaier P, et al. (2000). "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes". EMBO J. 19 (16): 4362–4371. doi:10.1093/emboj/19.16.4362. PMC 302028. PMID 10944119.
Ruhl M, Himmelspach M, Bahr GM, et al. (1994). "Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation". J. Cell Biol. 123 (6 Pt 1): 1309–1320. doi:10.1083/jcb.123.6.1309. PMC 2290910. PMID 8253832.
Steinkasserer A, Jones T, Sheer D, et al. (1995). "The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2". Genomics. 25 (3): 749–752. doi:10.1016/0888-7543(95)80025-H. PMID 7759117.
Koettnitz K, Wöhl T, Kappel B, et al. (1995). "Identification of a new member of the human eIF-5A gene family". Gene. 159 (2): 283–284. doi:10.1016/0378-1119(95)00136-T. PMID 7622067.
Koettnitz K, Kappel B, Baumruker T, et al. (1994). "The genomic structure encoding human initiation factor eIF-5A". Gene. 144 (2): 249–252. doi:10.1016/0378-1119(94)90385-9. PMID 7545941.
Park MH, Liu TY, Neece SH, Swiggard WJ (1986). "Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue". J. Biol. Chem. 261 (31): 14515–9. doi:10.1016/S0021-9258(18)66899-1. PMID 3095320.
Smit-McBride Z, Dever TE, Hershey JW, Merrick WC (1989). "Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein". J. Biol. Chem. 264 (3): 1578–83. doi:10.1016/S0021-9258(18)94226-2. PMID 2492279.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000253626 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "EIF5AL1 - eukaryotic translation initiation factor 5A like 1".

EIF5AL1

References

Further reading