ELP2

ELP2

Identifiers

ELP2, SHINC-2, STATIP1, StIP, elongator acetyltransferase complex subunit 2, MRT58

External IDs

OMIM: 616054; MGI: 1889642; GeneCards: ELP2

Gene location (Human)

Chr.	Chromosome 18 (human)

Band	18q12.2	Start	36,129,444 bp
Band	18q12.2	End	36,180,557 bp

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)

Band	18\|18 A2	Start	24,735,923 bp
Band	18\|18 A2	End	24,772,564 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

left ovary

Achilles tendon

right ovary

skin of abdomen

ganglionic eminence

skin of leg

epithelium of colon

right uterine tube

body of pancreas

canal of the cervix

Top expressed in

saccule

otic placode

motor neuron

facial motor nucleus

internal carotid artery

condyle

external carotid artery

primitive streak

utricle

fossa

More reference expression data

n/a

Gene ontology
Molecular function	RNA polymerase II complex binding protein kinase binding
Cellular component	histone acetyltransferase complex transcription elongation factor complex nucleus cytoplasm cytosol elongator holoenzyme complex
Biological process	regulation of transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated regulation of receptor signaling pathway via JAK-STAT tRNA wobble uridine modification
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


55250


58523


ENSG00000134759


ENSMUSG00000024271


Q6IA86


Q91WG4

RefSeq (mRNA)

NM_001242875 NM_001242876 NM_001242877 NM_001242878 NM_001242879
NM_018255 NM_001324465 NM_001324466 NM_001324467 NM_001324468 NM_001324469


NM_021448 NM_001360909

RefSeq (protein)

NP_001229804 NP_001229805 NP_001229806 NP_001229807 NP_001229808
NP_001311394 NP_001311395 NP_001311396 NP_001311397 NP_060725


NP_067423 NP_001347838

Location (UCSC)

Chr 18: 36.13 – 36.18 Mb

Chr 18: 24.74 – 24.77 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Elongator complex protein 2 is a protein that in humans is encoded by the ELP2 gene.

Interactions

ELP2 has been shown to interact with STAT3 and Janus kinase 1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134759 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024271 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
1 2 3 Collum RG, Brutsaert S, Lee G, Schindler C (Oct 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc Natl Acad Sci U S A. 97 (18): 10120–5. Bibcode:2000PNAS...9710120C. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
↑ "Entrez Gene: STATIP1 signal transducer and activator of transcription 3 interacting protein 1".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. Bibcode:2002PNAS...99.1241K. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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