EPB41L2

EPB41L2
Identifiers
Aliases	EPB41L2, 4.1-G, 4.1G, erythrocyte membrane protein band 4.1 like 2
External IDs	OMIM: 603237; MGI: 103009; GeneCards: EPB41L2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	131,063,322 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	25,523,519 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; sural nerve; ; tendon of biceps brachii; ; corpus callosum; ; dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; internal globus pallidus; ; trigeminal ganglion; ; right lung;
	Top expressed in
	neural layer of retina; ; tail of embryo; ; genital tubercle; ; lens; ; optic nerve; ; sciatic nerve; ; epithelium of lens; ; zygote; ; retinal pigment epithelium; ; spermatid;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; PH domain binding; actin binding; spectrin binding; cytoskeletal protein binding; structural constituent of cytoskeleton; protein binding;
Cellular component	extracellular exosome; cell junction; spectrin; nucleus; membrane; focal adhesion; nucleoplasm; cytoplasm; COP9 signalosome; cytoskeleton; cytosol; plasma membrane; cell cortex region; cell cortex;
Biological process	cortical actin cytoskeleton organization; actomyosin structure organization; positive regulation of protein localization to cell cortex; cell cycle; cell division; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2037
	13822
	ENSG00000079819
	ENSMUSG00000019978
	O43491
	O70318
NM_001135554; NM_001135555; NM_001199388; NM_001199389; NM_001252660;
	NM_001431; NM_001350299; NM_001350301; NM_001350302; NM_001350303; NM_001350304; NM_001350305; NM_001350306; NM_001350307; NM_001350308; NM_001350309; NM_001350310; NM_001350311; NM_001350312; NM_001350313; NM_001350314; NM_001350315; NM_001350320
NM_001199265; NM_013511; NM_001358751; NM_001358753; NM_001358754;
	NM_001358755
NP_001129026; NP_001129027; NP_001186317; NP_001239589; NP_001422;
	NP_001337228; NP_001337230; NP_001337231; NP_001337232; NP_001337233; NP_001337234; NP_001337235; NP_001337236; NP_001337237; NP_001337238; NP_001337239; NP_001337240; NP_001337241; NP_001337242; NP_001337243; NP_001337244; NP_001337249
NP_001186194; NP_038539; NP_001345680; NP_001345682; NP_001345683;
	NP_001345684; NP_001391726; NP_001391727; NP_001391728; NP_001391730; NP_001391731; NP_001391732; NP_001391734; NP_001391735; NP_001391736; NP_001391737; NP_001391738; NP_001391739; NP_001391740; NP_001391741; NP_001391742; NP_001391744; NP_001391745; NP_001391747; NP_001391748; NP_001391757; NP_001391758; NP_001391759; NP_001391760; NP_001391761; NP_001391762; NP_001391763; NP_001391764; NP_001391766; NP_001391767; NP_001391768; NP_001391769; NP_001391770; NP_001391771; NP_001391772; NP_001391773; NP_001391774; NP_001391775; NP_001391776; NP_001391777; NP_001391778; NP_001391779; NP_001391780; NP_001391781; NP_001391782; NP_001391783; NP_001391784
	Wikidata
View/Edit Human	View/Edit Mouse

Band 4.1-like protein 2 is a protein that in humans is encoded by the EPB41L2 gene.

Interactions

EPB41L2 has been shown to interact with FKBP2 and GRIA1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000079819 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019978 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Parra M, Gascard P, Walensky LD, Snyder SH, Mohandas N, Conboy JG (April 1998). "Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family". Genomics. 49 (2): 298–306. doi:10.1006/geno.1998.5265. PMID 9598318.
↑ Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG (December 1998). "Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human". Genomics. 54 (2): 348–50. doi:10.1006/geno.1998.5537. PMID 9828140.
↑ "Entrez Gene: EPB41L2 erythrocyte membrane protein band 4.1-like 2".
↑ Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH (April 1998). "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". The Journal of Cell Biology. 141 (1): 143–53. doi:10.1083/jcb.141.1.143. PMC 2132710. PMID 9531554.
↑ Shen L, Liang F, Walensky LD, Huganir RL (November 2000). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". The Journal of Neuroscience. 20 (21): 7932–40. doi:10.1523/jneurosci.20-21-07932.2000. PMC 6772741. PMID 11050113.

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH (April 1998). "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". The Journal of Cell Biology. 141 (1): 143–53. doi:10.1083/jcb.141.1.143. PMC 2132710. PMID 9531554.
Shen L, Liang F, Walensky LD, Huganir RL (November 2000). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". The Journal of Neuroscience. 20 (21): 7932–40. doi:10.1523/jneurosci.20-21-07932.2000. PMC 6772741. PMID 11050113.
Kontrogianni-Konstantopoulos A, Frye CS, Benz EJ, Huang SC (June 2001). "The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation". The Journal of Biological Chemistry. 276 (23): 20679–87. doi:10.1074/jbc.M010581200. PMID 11274145.
Gimm JA, An X, Nunomura W, Mohandas N (June 2002). "Functional characterization of spectrin-actin-binding domains in 4.1 family of proteins". Biochemistry. 41 (23): 7275–82. doi:10.1021/bi0256330. PMID 12044158.
Binda AV, Kabbani N, Lin R, Levenson R (September 2002). "D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N". Molecular Pharmacology. 62 (3): 507–13. doi:10.1124/mol.62.3.507. PMID 12181426. S2CID 19901660.
Delhommeau F, Vasseur-Godbillon C, Leclerc P, Schischmanoff PO, Croisille L, Rince P, Morinière M, Benz EJ, Tchernia G, Tamagnini G, Ribeiro L, Delaunay J, Baklouti F (October 2002). "A splicing alteration of 4.1R pre-mRNA generates 2 protein isoforms with distinct assembly to spindle poles in mitotic cells". Blood. 100 (7): 2629–36. doi:10.1182/blood.V100.7.2629. PMID 12239178.
Lu D, Yan H, Othman T, Turner CP, Woolf T, Rivkees SA (January 2004). "Cytoskeletal protein 4.1G binds to the third intracellular loop of the A1 adenosine receptor and inhibits receptor action". The Biochemical Journal. 377 (Pt 1): 51–9. doi:10.1042/BJ20030952. PMC 1223836. PMID 12974671.
Ralston KJ, Hird SL, Zhang X, Scott JL, Jin B, Thorne RF, Berndt MC, Boyd AW, Burns GF (August 2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large". The Journal of Biological Chemistry. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000079819 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019978 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9598318-5] Parra M, Gascard P, Walensky LD, Snyder SH, Mohandas N, Conboy JG (April 1998). "Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family". Genomics. 49 (2): 298–306. doi:10.1006/geno.1998.5265. PMID 9598318.

[pmid9828140-6] Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG (December 1998). "Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human". Genomics. 54 (2): 348–50. doi:10.1006/geno.1998.5537. PMID 9828140.

[entrez-7] "Entrez Gene: EPB41L2 erythrocyte membrane protein band 4.1-like 2".

[pmid9531554-8] Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH (April 1998). "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". The Journal of Cell Biology. 141 (1): 143–53. doi:10.1083/jcb.141.1.143. PMC 2132710. PMID 9531554.

[pmid11050113-9] Shen L, Liang F, Walensky LD, Huganir RL (November 2000). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". The Journal of Neuroscience. 20 (21): 7932–40. doi:10.1523/jneurosci.20-21-07932.2000. PMC 6772741. PMID 11050113.

EPB41L2

Interactions

References

Further reading