Dematin

DMTN
Identifiers
Aliases	DMTN, DMT, EPB49, dematin actin binding protein
External IDs	OMIM: 125305; MGI: 99670; GeneCards: DMTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QZP, 1ZV6
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,082,527 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,636,048 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; Brodmann area 10; ; nucleus accumbens; ; amygdala; ; Brodmann area 9; ; caudate nucleus; ; right hemisphere of cerebellum;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; fetal liver hematopoietic progenitor cell; ; entorhinal cortex; ; perirhinal cortex; ; primary motor cortex; ; prefrontal cortex; ; olfactory tubercle; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	spectrin binding; protein binding; actin binding; signaling receptor binding; protein self-association; actin filament binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; cortical cytoskeleton; plasma membrane; platelet dense tubular network membrane; cell projection membrane; actin filament; actin cytoskeleton; spectrin-associated cytoskeleton; perinuclear region of cytoplasm; endomembrane system; cytoskeleton; postsynaptic density; cytoplasmic vesicle;
Biological process	negative regulation of cell-substrate adhesion; regulation of lamellipodium assembly; cellular response to calcium ion; regulation of filopodium assembly; actin filament reorganization; regulation of actin cytoskeleton organization; negative regulation of peptidyl-threonine phosphorylation; positive regulation of wound healing; actin filament bundle assembly; positive regulation of substrate adhesion-dependent cell spreading; negative regulation of protein targeting to membrane; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of blood coagulation; calcium-mediated signaling using extracellular calcium source; cytoskeleton organization; actin filament capping; transmembrane transport; negative regulation of peptidyl-serine phosphorylation; positive regulation of integrin-mediated signaling pathway; protein secretion by platelet; negative regulation of substrate adhesion-dependent cell spreading; calcium-mediated signaling using intracellular calcium source; positive regulation of fibroblast migration; negative regulation of focal adhesion assembly; actin cytoskeleton organization; positive regulation of platelet aggregation; cellular response to cAMP; erythrocyte development; regulation of cell shape; protein-containing complex assembly; lamellipodium assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2039
	13829
	ENSG00000158856
	ENSMUSG00000022099
	Q08495
	Q9WV69
NM_001114135; NM_001114136; NM_001114137; NM_001114138; NM_001114139;
	NM_001302816; NM_001302817; NM_001978; NM_001323378; NM_001323380; NM_001323381; NM_001323382; NM_001323383; NM_001323384; NM_001323385; NM_001323387; NM_001323388; NM_001323389; NM_001323390; NM_001323391; NM_001323392; NM_001323393; NM_001323394; NM_001323395; NM_001323396; NM_001323397; NM_001323398; NM_001323399; NM_001323400; NM_001323401; NM_001323379; NM_001387723; NM_001387726; NM_001387727; NM_001387728; NM_001387730; NM_001387732; NM_001387734; NM_001387735; NM_001387736; NM_001387737; NM_001387742; NM_001387743; NM_001387744; NM_001387745; NM_001387750; NM_001387751; NM_001387752; NM_001387753; NM_001387754; NM_001387755; NM_001387756; NM_001387757
NM_001252662; NM_001252663; NM_001252664; NM_001252665; NM_001252666;
	NM_013514; NM_001360024; NM_001360025; NM_001360026; NM_001360027; NM_001360028; NM_001360029; NM_001360030
NP_001107607; NP_001107608; NP_001107609; NP_001107610; NP_001107611;
	NP_001289745; NP_001289746; NP_001310307; NP_001310308; NP_001310309; NP_001310310; NP_001310311; NP_001310312; NP_001310313; NP_001310314; NP_001310316; NP_001310317; NP_001310318; NP_001310319; NP_001310320; NP_001310321; NP_001310322; NP_001310323; NP_001310324; NP_001310325; NP_001310326; NP_001310327; NP_001310328; NP_001310329; NP_001310330; NP_001969
NP_001239591; NP_001239592; NP_001239593; NP_001239594; NP_001239595;
	NP_038542; NP_001346953; NP_001346954; NP_001346955; NP_001346956; NP_001346957; NP_001346958; NP_001346959
	Wikidata
View/Edit Human	View/Edit Mouse

Dematin is a protein that in humans is encoded by the DMTN gene (formerly EPB49). Dematin functions to stabilize the cytoskeleton structure of red blood cells. In particular, it binds to actin, and induces bundling.